Grape Seed Proanthocyanidins Modulate the Hepatic Molecular Clock via MicroRNAs,Molecular Nutrition & Food Research

当前位置： X-MOL 学术 › Mol. Nutr. Food Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Grape Seed Proanthocyanidins Modulate the Hepatic Molecular Clock via MicroRNAs
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-10-03 , DOI: 10.1002/mnfr.202200443
Francesca Manocchio ₁ , Jorge R Soliz-Rueda ₁ , Aleix Ribas-Latre ₁ , Francisca Isabel Bravo ₁ , Anna Arola-Arnal ₁ , Manuel Suarez ₁ , Begoña Muguerza ₁

Affiliation

Circadian rhythm is an endogenous and self-sustained timing system, responsible for the coordination of daily processes in 24-h timescale. It is regulated by an endogenous molecular clock, which is sensitive to external cues as light and food. This study has previously shown that grape seed proanthocyanidins extract (GSPE) regulates the hepatic molecular clock. Moreover, GSPE is known to interact with some microRNAs (miRNAs). Therefore, the aim of this study is to evaluate if the activity of GSPE as modulator of hepatic clock genes can be mediated by miRNAs.

中文翻译：

葡萄籽原花青素通过 MicroRNA 调节肝脏分子钟

昼夜节律是一个内生的、自我维持的计时系统，负责协调 24 小时时间尺度内的日常过程。它受到内源性分子钟的调节，该分子钟对光和食物等外部信号敏感。这项研究此前已表明葡萄籽原花青素提取物 (GSPE) 调节肝脏分子钟。此外，已知 GSPE 会与一些 microRNA (miRNA) 相互作用。因此，本研究的目的是评估 GSPE 作为肝时钟基因调节剂的活性是否可以由 miRNA 介导。

更新日期：2022-10-03

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11