Cystine Induced-mTORC2 Activation through Promoting Sin1 Phosphorylation to Suppress Cancer Cell Ferroptosis,Molecular Nutrition & Food Research

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Cystine Induced-mTORC2 Activation through Promoting Sin1 Phosphorylation to Suppress Cancer Cell Ferroptosis
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-10-03 , DOI: 10.1002/mnfr.202200186
GuoYan Wang ₁ , Lei Chen ₂ , SenLin Qin ₁ , YiNing Zheng ₁ , Chao Xia ₁ , JunHu Yao ₁ , Ping Wang ₃ , Lu Deng ₁

Affiliation

Mechanistic target of rapamycin (mTOR) serves as a central signaling node in the coordination of cell growth and metabolism, and it functions via two distinct complexes, namely, mTOR complex 1 (mTORC1) and mTORC2. mTORC1 plays a crucial role in sensing amino acids, whereas mTORC2 involves in sensing growth factors. However, it remains largely unclear whether mTORC2 can sense amino acids and the mechanism by which amino acids regulate mTORC2 has not been studied.

中文翻译：

胱氨酸诱导-mTORC2激活通过促进Sin1磷酸化抑制癌细胞铁死亡

雷帕霉素 (mTOR) 的机制靶点作为协调细胞生长和代谢的中央信号节点，它通过两个不同的复合物发挥作用，即 mTOR 复合物 1 (mTORC1) 和 mTORC2。mTORC1 在感知氨基酸方面起着至关重要的作用，而 mTORC2 参与感知生长因子。然而，目前尚不清楚 mTORC2 是否可以感知氨基酸，氨基酸调节 mTORC2 的机制也尚未得到研究。

更新日期：2022-10-03

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