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Advancements in antimicrobial nanoscale materials and self-assembling systems
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2022-10-03 , DOI: 10.1039/d1cs00915j Jack A Doolan 1, 2 , George T Williams 3 , Kira L F Hilton 1 , Rajas Chaudhari 1 , John S Fossey 3 , Benjamin T Goult 2 , Jennifer R Hiscock 1
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2022-10-03 , DOI: 10.1039/d1cs00915j Jack A Doolan 1, 2 , George T Williams 3 , Kira L F Hilton 1 , Rajas Chaudhari 1 , John S Fossey 3 , Benjamin T Goult 2 , Jennifer R Hiscock 1
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Antimicrobial resistance is directly responsible for more deaths per year than either HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at least $100 trillion between 2014 and 2050. Already heralded as one of the greatest threats to human health, the onset of the coronavirus pandemic has accelerated the prevalence of antimicrobial resistant bacterial infections due to factors including increased global antibiotic/antimicrobial use. Thus an urgent need for novel therapeutics to combat what some have termed the ‘silent pandemic’ is evident. This review acts as a repository of research and an overview of the novel therapeutic strategies being developed to overcome antimicrobial resistance, with a focus on self-assembling systems and nanoscale materials. The fundamental mechanisms of action, as well as the key advantages and disadvantages of each system are discussed, and attention is drawn to key examples within each field. As a result, this review provides a guide to the further design and development of antimicrobial systems, and outlines the interdisciplinary techniques required to translate this fundamental research towards the clinic.
中文翻译：
抗菌纳米材料和自组装系统的进展
抗菌素耐药性每年直接造成的死亡人数比艾滋病毒/艾滋病或疟疾还要多，预计 2014 年至 2050 年间将造成至少 100 万亿美元的累计社会财政负担。抗生素耐药性已被视为人类健康面临的最大威胁之一。由于全球抗生素/抗微生物药物使用增加等因素，冠状病毒大流行的爆发加速了耐药细菌感染的流行。因此，显然迫切需要新的疗法来对抗某些人所说的“无声的流行病”。这篇综述作为研究资料库和为克服抗菌素耐药性而开发的新型治疗策略的概述，重点是自组装系统和纳米级材料。讨论了基本作用机制以及每个系统的主要优点和缺点，并重点关注每个领域内的关键示例。因此，这篇综述为抗菌系统的进一步设计和开发提供了指导，并概述了将这项基础研究转化为临床所需的跨学科技术。
更新日期：2022-10-03
中文翻译：
抗菌纳米材料和自组装系统的进展
抗菌素耐药性每年直接造成的死亡人数比艾滋病毒/艾滋病或疟疾还要多，预计 2014 年至 2050 年间将造成至少 100 万亿美元的累计社会财政负担。抗生素耐药性已被视为人类健康面临的最大威胁之一。由于全球抗生素/抗微生物药物使用增加等因素，冠状病毒大流行的爆发加速了耐药细菌感染的流行。因此，显然迫切需要新的疗法来对抗某些人所说的“无声的流行病”。这篇综述作为研究资料库和为克服抗菌素耐药性而开发的新型治疗策略的概述，重点是自组装系统和纳米级材料。讨论了基本作用机制以及每个系统的主要优点和缺点，并重点关注每个领域内的关键示例。因此，这篇综述为抗菌系统的进一步设计和开发提供了指导，并概述了将这项基础研究转化为临床所需的跨学科技术。
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