Prenatal exposure to plastic chemicals has been associated with alterations to early-life immune function in children. However, previous studies have generally been small and focused on limited repertoires of immune indices. In a large population-based pre-birth cohort (n = 1074), third-trimester measurements of eight phthalate metabolites and three analogues of bisphenols were used to estimate prenatal exposure to phthalate and bisphenol compounds. In cord blood, immune cell populations were measured by flow cytometry and an extensive panel of cytokines and chemokines were measured by multiplex immunoassay. We used these cord blood analytes to estimate “early life” immune profiles. The full study sample comprises data from 774 infants with prenatal plastic metabolite measurements and any cord blood immune data. Multiple linear regression analysis was used to evaluate whether prenatal phthalate and bisphenol exposure was prospectively associated with cord blood immune cell populations and cytokine and chemokine levels. Generally, inverse associations were observed between prenatal phthalate exposure and cord blood immune indices. Higher exposure to di-n-butyl phthalate was associated with lower cord blood levels of platelet-derived growth factor (PDGF) and interferon gamma-induced protein 10 (IP-10); higher exposure to the sum of dibutyl phthalates was associated with lower cord blood levels of IP-10; and higher exposure to benzyl butyl phthalate was associated with lower cord blood levels of interleukin 1 beta (IL-1β). There was less evidence of associations between bisphenols and cord blood immune indices. These results extend previous work examining prenatal plastic chemical exposure and early-life immune development and highlight the importance of further examination of potential associations with health-related outcomes.

产前接触塑料化学品与儿童早期免疫功能的改变有关。然而，以前的研究通常规模较小，并且集中在有限的免疫指标库上。在一个基于人群的大型出生前队列 (n = 1074) 中，使用孕晚期测量的八种邻苯二甲酸酯代谢物和三种双酚类似物来估计产前对邻苯二甲酸酯和双酚化合物的暴露。在脐带血中，通过流式细胞术测量免疫细胞群，并通过多重免疫测定法测量大量细胞因子和趋化因子。我们使用这些脐带血分析物来估计“生命早期”的免疫特征。完整的研究样本包括来自 774 名婴儿的产前塑料代谢物测量数据和任何脐带血免疫数据。多元线性回归分析用于评估产前邻苯二甲酸酯和双酚暴露是否与脐带血免疫细胞群和细胞因子和趋化因子水平相关。一般来说，在产前邻苯二甲酸酯暴露和脐带血免疫指数之间观察到负相关。较高的邻苯二甲酸二正丁酯暴露与较低的脐血血小板衍生生长因子 (PDGF) 和干扰素 γ 诱导蛋白 10 (IP-10) 水平相关；较高的邻苯二甲酸二丁酯总暴露量与较低的脐带血 IP-10 水平相关；较高的邻苯二甲酸苄基丁酯暴露与较低的白细胞介素 1 β (IL-1β) 水平相关。双酚与脐带血免疫指数之间关联的证据较少。