DHA-Enriched Phospholipids Exhibit Anti-Depressant Effects by Immune and Neuroendocrine Regulation in Mice: A Study on Dose- and Structure-Activity Relationship,Molecular Nutrition & Food Research

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DHA-Enriched Phospholipids Exhibit Anti-Depressant Effects by Immune and Neuroendocrine Regulation in Mice: A Study on Dose- and Structure-Activity Relationship
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-09-30 , DOI: 10.1002/mnfr.202200089
Cheng-Cheng Wang ₁ , Jun-Yi Wang ₂ , Hao-Hao Shi ₁ , Ying-Cai Zhao ₁ , Jin-Yue Yang ₁ , Yu-Ming Wang _{1,

3} , Teruyoshi Yanagita ₄ , Chang-Hu Xue _{1,

3} , Tian-Tian Zhang ₁

Affiliation

It has been reported that eicosapentaenoic acid (EPA), especially EPA-enriched phospholipids (EPA-PL), significantly ameliorates depression-like behavior in mice, while the corresponding effect of docosahexaenoic acid (DHA) is weak. However, it is still unclear whether the limited effect of DHA on alleviating depression is remedied by dose and chemical structure adjustment to DHA-PL.

中文翻译：

富含 DHA 的磷脂通过免疫和神经内分泌调节在小鼠中表现出抗抑郁作用：剂量和结构活性关系的研究

据报道，二十碳五烯酸 (EPA)，尤其是富含 EPA 的磷脂 (EPA-PL)，可显着改善小鼠的抑郁样行为，而二十二碳六烯酸 (DHA) 的相应作用较弱。然而，目前尚不清楚 DHA 对缓解抑郁症的有限作用是否可以通过调整 DHA-PL 的剂量和化学结构来弥补。

更新日期：2022-09-30

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