DNA variants that modulate life span provide insight into determinants of health, disease, and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program (ITP), we detected a sex-independent quantitative trait locus (QTL) on chromosome 12 and identified sex-specific QTLs, some of which we detected only in older mice. Similar relations between life history and longevity were uncovered in mice and humans, underscoring the importance of early access to nutrients and early growth. We identified common age- and sex-specific genetic effects on gene expression that we integrated with model organism and human data to create a hypothesis-building interactive resource of prioritized longevity and body weight genes. Finally, we validated Hipk1 , Ddost , Hspg2 , Fgd6 , and Pdk1 as conserved longevity genes using Caenorhabditis elegans life-span experiments.

中文翻译：

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异质小鼠种群中长寿的性别和年龄依赖遗传学

调节寿命的 DNA 变异提供了对健康、疾病和衰老的决定因素的洞察力。通过对干预测试计划 (ITP) 的 UM-HET3 小鼠的分析，我们在 12 号染色体上检测到一个与性别无关的数量性状基因座 (QTL)，并确定了性别特异性 QTL，其中一些我们仅在老年小鼠中检测到。在老鼠和人类身上发现了生活史和长寿之间的相似关系，强调了早期获取营养和早期生长的重要性。我们确定了常见的年龄和性别特异性遗传对基因表达的影响，我们将其与模式生物和人类数据相结合，以创建优先长寿和体重基因的假设构建互动资源。最后，我们验证了Hipk1,Ddost,Hspg2,Fgd6， 和PDK1作为保守的长寿基因使用秀丽隐杆线虫寿命实验。