Background

Nicotine addiction is a public health problem. Our hypothesis was that the degree of nicotine dependence is positively correlated with the perceived intensity of acute pain.

Materials and methods

A single-center prospective comparative observational study was conducted from 2019 to 2021. Patients included presented distal phalanx extra-articular trauma of less than 24 hours’ progression. We compared a group of smokers with a group of non-smokers. A Digital Pain Scale (DPS) was assessed at time of trauma, at first consultation, and once a day until the fifth day post-trauma. A Fagerström test was performed. The primary endpoints were the correlation between dependence and DPS and the correlation between the amount of tobacco consumed and DPS. The secondary endpoints were analgesic consumption according to Fagerström, DPS and tobacco consumption.

Results

Sixty-seven patients were included: 26 smokers, 41 non-smokers. No significant correlation was found between dependence level or amount of tobacco used and DPS. Consumption of level II analgesics was significantly 2-fold higher in the smoking group on the second, third and fifth day: respectively, 2.15 tablets versus 1.22 (p = 0.02), 1.27 versus 0.49 (p = 0.01), and 0.69 versus 0.20 (p = 0.04).

Conclusion

Patients who smoke are exposed to more frequent and more intense pain and consume more palliative painkillers.

Level of evidence

IIB; exposed vs. non-exposed cohort.

中文翻译：

---

手指压伤和尼古丁中毒后出现急性疼痛。香烟永远是一个虚假的朋友。一项前瞻性研究

背景

尼古丁成瘾是一个公共健康问题。我们的假设是尼古丁依赖程度与感知的急性疼痛强度呈正相关。

材料和方法

 2019年至2021年进行了一项单中心前瞻性比较观察研究。患者包括出现进展时间小于24小时的远端指骨关节外损伤的患者。我们将一组吸烟者与一组不吸烟者进行了比较。在创伤发生时、第一次就诊时评估数字疼痛量表 (DPS)，每天评估一次直至创伤后第五天。进行了 Fagerström 测试。主要终点是依赖性与 DPS 之间的相关性以及烟草消费量与 DPS 之间的相关性。次要终点是根据 Fagerström 的镇痛消耗量、DPS 和烟草消耗量。

结果

包括 67 名患者：26 名吸烟者，41 名不吸烟者。依赖程度或烟草使用量与 DPS 之间没有发现显着相关性。吸烟组在第二天、第三天和第五天的 II 级镇痛药用量显着增加两倍：分别为 2.15 片 vs 1.22 (p = 0.02)、1.27 片 vs 0.49 (p = 0.01) 和 0.69 片 vs 0.20 (  p  = 0.01  )  。p  =  0.04）。

结论

吸烟的患者会遭受更频繁、更剧烈的疼痛，并服用更多的姑息止痛药。

证据级别

ⅡB；暴露组与非暴露组。