Breast cancer is one of the most important causes of premature mortality in women worldwide. Around 12% of breast cancer patients will develop metastatic disease, a stage associated with poor prognosis, and only 26% of patients are likely to survive for at least 5 years after being diagnosed. Although the most common sites where breast cancer tends to spread are bones, lungs, brain, and liver, it is important that physicians consider other less frequent organs and viscera, like the bladder, as a target destination. In this article we report our experience with this rare form of metastases and a systematic literature review. We analyzed case reports, case series, and review articles present in PubMED/MEDLINE up to March 2022. We excluded the nonrelevant articles, editorials, letters to the editor, and articles written in other languages. We identified a total of 302 articles, with 200 articles being removed before screening; therefore, the total number of abstracts reviewed was 102. Fifty-five articles were excluded before full text review because they did not meet the inclusion criteria, and one article was not retrievable. Therefore, we included a total of 45 articles in this review. The intention of this review is to highlight the importance of the early detection of bladder metastases and to facilitate the diagnostic process for the responsible physician. The most common signs and symptoms and breast cancer subtype associated with bladder metastases, as well as overall survival after their detection, were all assessed. Bladder metastases from metastatic breast cancer are prevalent in the invasive, lobular breast cancer subtype; most patients present with hematuria (39.5%) and the relative 5-year survival rate is 2%. The main limitations of this review are the low number of cases reported in the literature, clinical and pathological differences between the individual cases, and absence of the control group. This study was not funded.

乳腺癌是全球女性过早死亡的最重要原因之一。大约 12% 的乳腺癌患者会发展为转移性疾病，这是一个与预后不良相关的阶段，只有 26% 的患者在确诊后可能存活至少 5 年。虽然乳腺癌最常见的扩散部位是骨骼、肺、脑和肝脏，但医生必须将其他不太常见的器官和内脏（如膀胱）视为目标目的地。在本文中，我们报告了我们对这种罕见的转移形式的经验和系统的文献回顾。我们分析了截至 2022 年 3 月 PubMED/MEDLINE 中出现的病例报告、病例系列和评论文章。我们排除了不相关的文章、社论、致编辑的信以及以其他语言撰写的文章。我们共确定了 302 篇文章，其中 200 篇文章在筛选前被删除；因此，审查的摘要总数为102。55篇文章在全文审查之前被排除在外，因为它们不符合纳入标准，1篇文章无法检索。因此，我们在这篇综述中总共收录了 45 篇文章。这篇综述的目的是强调早期发现膀胱转移瘤的重要性，并促进负责医生的诊断过程。与膀胱转移相关的最常见的体征和症状和乳腺癌亚型，以及检测后的总生存期都进行了评估。转移性乳腺癌的膀胱转移在浸润性小叶乳腺癌亚型中很普遍。大多数患者出现血尿 (39. 5%），相对 5 年生存率为 2%。本综述的主要局限性是文献报道的病例数少、个体病例之间的临床和病理差异以及对照组的缺失。这项研究没有得到资助。