Simple Summary: Adolescents and young adults (AYA) with cancer often fall through gaps between children’s and adults’ cancer services. They are consequently under-represented in clinical trials, and their survival is often inferior to that of children or adults with the same tumor type; in this paper, we use the example of central nervous system germ cell tumors (CNS-GCT), as a model of AYA tumor to illustrate this challenge. We describe how we have built bridges between pediatric and adult oncology, how this can apply to other types of brain tumors, and discuss ways to promote cancer care in the AYA population.Adolescents and young adults (AYA) with cancer are under-represented in clinical trials and have thus not benefited from the same improvement in outcomes as either younger or older patients. Central nervous system germ cell tumors (CNS-GCT) represent an ideal model of AYA tumor as their incidence peaks during adolescence and young adulthood. Since the early 90’s, SIOP (International Society of Pediatric Oncology) has launched two successive European trials: SIOP CNS-GCT96 (January 1996 to December 2005) and SIOP CNS-GCTII protocols (October 2011 to July 2018), for CNS-GCTs. With the removal of the upper age limit in the SIOP CNS-GCTII trial, and closer collaboration between pediatric and adult oncologists within AYA multidisciplinary tumor boards, the proportion of adults enrolled in France has dramatically increased over time. The current article will use the example of CNS-GCT to illustrate how to build a bridge between pediatric and adult oncology, how this can apply to other types of brain tumors, and how to promote cancer care in the AYA population.

中文翻译：

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中枢神经系统生殖细胞肿瘤，典型的 AYA 肿瘤和儿科和神经肿瘤学合作模型，来自 EURACAN 域 10 组的评论

简单总结：患有癌症的青少年和年轻成人 (AYA) 经常会因儿童和成人癌症服务之间的差距而陷入困境。因此，他们在临床试验中的代表性不足，而且他们的生存期通常不如患有相同肿瘤类型的儿童或成人；在本文中，我们使用中枢神经系统生殖细胞肿瘤 (CNS-GCT) 作为 AYA 肿瘤的模型来说明这一挑战。我们描述了我们如何在儿科和成人肿瘤学之间建立桥梁，这如何适用于其他类型的脑肿瘤，并讨论在 AYA 人群中促进癌症护理的方法。患有癌症的青少年和年轻人 (AYA) 在临床试验，因此没有从与年轻或老年患者相同的结果改善中获益。中枢神经系统生殖细胞肿瘤 (CNS-GCT) 代表了 AYA 肿瘤的理想模型，因为它们的发病率在青春期和青年期达到高峰。自上世纪 90 年代初以来，SIOP（国际儿科肿瘤学会）针对 CNS-GCT 连续开展了两项欧洲试验：SIOP CNS-GCT96（1996 年 1 月至 2005 年 12 月）和 SIOP CNS-GCTII 方案（2011 年 10 月至 2018 年 7 月）。随着 SIOP CNS-GCTII 试验中年龄上限的取消，以及 AYA 多学科肿瘤委员会内儿科和成人肿瘤学家之间更密切的合作，随着时间的推移，在法国注册的成年人比例急剧增加。当前文章将以 CNS-GCT 为例，说明如何在儿科和成人肿瘤学之间架起一座桥梁，以及如何将其应用于其他类型的脑肿瘤，