Objective

Some studies have pointed to gabapentinoids as promising medications in postoperative pain control. The objective of the present study was to evaluate the efficacy of pregabalin in reducing postoperative pain in tonsillectomy and lateral pharyngoplasties.

Study design

Double-blind randomized controlled trial.

Setting

Tertiary care center.

Methods

A double-blind randomized controlled trial was conducted with patients undergoing tonsillectomies and lateral pharyngoplasties between Aug 29, 2017, and Oct 31, 2020. Data of interest such as opioid consumption, pain scores, and adverse outcomes such as dizziness, nausea, headache, and sedation within 7 days following surgeries were analyzed.

Results

No statistically significant difference was observed in pain scores and opioid consumption between the groups studied in the pilot project. The use of pregabalin was associated with lower incidence of dizziness compared to controls.

Conclusion

Gabapentinoids, especially pregabalin, are drugs whose potential for controlling pain after pharyngeal surgery, such as tonsillectomy and sleep apnea surgery, still needs to be more fully evaluated. After the conclusion of the present study, we hope to answer this question about the role of pregabalin in oropharyngeal surgeries.

中文翻译：

---

普瑞巴林在侧咽成形术和扁桃体切除术后是否起到镇痛作用？试点研究

客观的

一些研究指出加巴喷丁类药物在术后疼痛控制方面是有前途的药物。本研究的目的是评估普瑞巴林在减轻扁桃体切除术和侧咽成形术术后疼痛方面的疗效。

学习规划

双盲随机对照试验。

环境

三级护理中心。

方法

对在 2017 年 8 月 29 日至 2020 年 10 月 31 日期间接受扁桃体切除术和侧咽成形术的患者进行了一项双盲随机对照试验。感兴趣的数据包括阿片类药物的消耗量、疼痛评分和头晕、恶心、头痛等不良后果，分析了手术后 7 天内的镇静情况。

结果

在试点项目中研究的组之间，在疼痛评分和阿片类药物消耗方面没有观察到统计学上的显着差异。与对照组相比，普瑞巴林的使用与较低的头晕发生率相关。

结论

加巴喷丁类药物，尤其是普瑞巴林，是一种在扁桃体切除术和睡眠呼吸暂停手术等咽部手术后控制疼痛的药物，仍需要更全面地评估。在本研究结束后，我们希望回答这个关于普瑞巴林在口咽手术中的作用的问题。