Neuronal loss of the nucleus basalis of Meynert in primary progressive aphasia is associated with Alzheimer's disease neuropathological changes,Alzheimer's & Dementia

当前位置： X-MOL 学术 › Alzheimers Dement. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Neuronal loss of the nucleus basalis of Meynert in primary progressive aphasia is associated with Alzheimer's disease neuropathological changes
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2022-09-28 , DOI: 10.1002/alz.12794
Jolien Schaeverbeke _{1,

2} , Sandra O Tomé ₂ , Alicja Ronisz ₂ , Simona Ospitalieri ₂ , Christine A F von Arnim _{3,

4} , Markus Otto _{3,

5} , Rik Vandenberghe _{1,

6} , Dietmar Rudolf Thal _{2,

7}

Affiliation

Imaging studies indicated basal forebrain reduction in primary progressive aphasia (PPA), which might be a candidate marker for cholinergic treatment. Nucleus basalis of Meynert (nbM) neuronal loss has been reported, but a systematic quantitative neuropathological assessment including the three clinical PPA variants is lacking.

中文翻译：

原发性进行性失语症中 Meynert 基底核的神经元丢失与阿尔茨海默病神经病理学变化有关

影像学研究表明原发性进行性失语症 (PPA) 的基底前脑减少，这可能是胆碱能治疗的候选标志物。已报道 Meynert (nbM) 神经元丢失的基底核，但缺乏包括三种临床 PPA 变体的系统定量神经病理学评估。

更新日期：2022-09-28

点击分享查看原文

点击收藏

阅读更多本刊最新论文

全部期刊列表>>