CXC chemokine ligand-10 (CXCL10) is a small (10 kDa) secretory protein in the CXC subfamily of cytokines. CXCL10 has been reported to play an important role in antitumor immunity as a chemotactic factor. Tumor development is always accompanied by the formation of an immunosuppressive tumor microenvironment, and the role of CXCL10 in tumor immunosuppression remains unclear. Here, we reported that CXCL10 expression was significantly upregulated in mice with melanoma, and tumor cells secreted large amounts of CXCL10. Myeloid-derived suppressor cells (MDSCs) are an important part of the immunosuppressive tumor microenvironment. Our results showed that CXCL10 promoted the proliferation of monocyte-like (mo)-MDSCs by activating the p38 MAPK signaling pathway through CXCR3, which led to the abnormal accumulation of mo-MDSCs under tumor conditions. This finding provides a new understanding of the mechanism by which a tumor-induced immunosuppressive microenvironment forms and suggests that CXCL10 could be a potential intervention target for slowing tumor progression.

中文翻译：

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CXC 趋化因子配体 10 在肿瘤条件下通过激活 p38 MAPK 信号促进单核细胞样髓源性抑制细胞的积累

CXC 趋化因子配体 10 (CXCL10) 是细胞因子 CXC 亚家族中的一种小 (10 kDa) 分泌蛋白。据报道，CXCL10 作为趋化因子在抗肿瘤免疫中发挥重要作用。肿瘤的发展总是伴随着免疫抑制肿瘤微环境的形成，而CXCL10在肿瘤免疫抑制中的作用尚不清楚。在这里，我们报道了黑色素瘤小鼠的 CXCL10 表达显着上调，并且肿瘤细胞分泌大量 CXCL10。髓源性抑制细胞 (MDSC) 是免疫抑制性肿瘤微环境的重要组成部分。我们的研究结果表明，CXCL10 通过 CXCR3 激活 p38 MAPK 信号通路促进单核细胞样 (mo)-MDSCs 的增殖，从而导致 mo-MDSCs 在肿瘤条件下异常积累。