Objective

Anterior cervical corpectomy and fusion (ACCF) has been widely used in the treatment of cervical spondylotic myelopathy (CSM) but is accompanied by unavoidable motion loss and destruction of vertebra. We aim to evaluate the range of motion (ROM) of caprine cervical spine constructs implanted with cervical artificial disc and vertebra system (ADVS). The purpose of this study was to investigate the biomechanical properties of the ADVS from an in vivo caprine cervical spine non-fusion model.

Methods

Twelve goats were randomly divided into ADVS or control group, with 6 animals in each group. The animals in the ADVS group were implanted with ADVS at the C₄ level. The cervical spine constructs were harvested 6 months after the operation. The ROM of cervical spine specimens in the ADVS group was recorded. Biomechanical testing of the specimens in the control group were conducted to evaluate the ROM of the cervical spine specimens under intact and fixed condition (C₃-C₅) by an anterior plate, respectively.

Results

The biomechanical outcomes showed that the ROM of the levels (C₃-C₅) implanted with ADVS was maintained. The ROM in the adjacent level (C_2-3) did not increase significantly comparing with intact group.

Conclusions

In general, ADVS could preserve the ROM of operative levels and could reconstruct the height of the vertebra. ADVS did not increase the ROM of upper adjacent level. This device provides a non-fusion method for the treatment of patients suffering from CSM. However, improvements on the design of ADVS are still needed.

Translational potential statement

This study introduced a novel cervical spinal implant, which was designed to have the ability of motion preservation and vertebra construction. Our study provided a non-fusion procedure in the treatment of CSM after ACCF.

中文翻译：

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活体山羊颈椎非融合模型中新型人工颈椎的生物力学

客观的

颈椎前路椎体切除融合术（ACCF）已广泛用于治疗脊髓型颈椎病（CSM），但伴随着不可避免的运动丧失和椎体破坏。我们旨在评估植入颈椎人工椎间盘和椎骨系统 (ADVS) 的山羊颈椎结构的活动范围 (ROM)。本研究的目的是从体内山羊颈椎非融合模型中研究 ADVS 的生物力学特性。

方法

12只山羊随机分为ADVS组或对照组，每组6只。ADVS组的动物被植入C ₄水平的ADVS。颈椎结构在手术后 6 个月收获。记录ADVS组颈椎标本的ROM。对对照组的标本进行生物力学测试，分别评估颈椎标本在完整和固定条件下（C ₃ -C ₅）前板的ROM。

结果

生物力学结果表明，植入 ADVS的水平 (C ₃ -C _{5 ) 的 ROM 得以维持。}与完整组相比，相邻水平（C _2-3）的ROM没有显着增加。

结论

一般来说，ADVS可以保留手术节段的ROM，并可以重建椎骨的高度。ADVS没有增加上相邻层的ROM。该设备为治疗患有 CSM 的患者提供了一种非融合方法。但是，仍然需要改进 ADVS 的设计。

翻译潜力陈述

本研究介绍了一种新型颈椎植入物，该植入物被设计成具有运动保存和椎体结构的能力。我们的研究为 ACCF 后 CSM 的治疗提供了一种非融合程序。