Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism. HNF4α-related diseases include non-alcoholic fatty liver disease (NAFLD), obesity, hypertension, hyperlipidemia, metabolic syndrome and diabetes mellitus. Recently, HNF4α has been emerging as a key player in a variety of cancers. In this review, we summarized the role and mechanism of HNF4α in different types of cancers, especially in liver and colorectal cancer, aiming to provide additional guidance for intervention of these diseases.

肝细胞核因子 4 α (HNF4α) 是主要在肝、肾、肠和内分泌胰腺中表达的主要转录因子。它调节涉及胚胎发育和代谢的多个靶基因。HNF4α相关疾病包括非酒精性脂肪肝（NAFLD）、肥胖、高血压、高脂血症、代谢综合征和糖尿病。最近，HNF4α 已成为各种癌症的关键参与者。在这篇综述中，我们总结了HNF4α在不同类型癌症中的作用和机制，特别是在肝癌和结直肠癌中，旨在为这些疾病的干预提供额外的指导。