Measuring regional cerebral blood flow (rCBF) after revascularization for moyamoya disease, as a type of ischemic cerebrovascular disease, is crucial. This study aims to validate our novel technology that combines near-infrared spectroscopy (NIRS) with a frequency filter to extract the arterial component. We measured rCBF before and after revascularization for moyamoya disease and at the end of the surgery using NIRO-200NX (Hamamatsu Photonics, Japan) and indocyanine green (ICG). rCBF was calculated using Fick’s principle, change in arterial ICG concentrations, and maximum arterial ICG concentration. rCBF measured with NIRS (rCBF_N) was compared with pre- and postoperative rCBF measured with SPECT (rCBF_S). Thirty-four procedures were analyzed. rCBF_N increased from baseline to end of the surgery (mean difference (MD), 2.99 ml/min/100 g; 95% confidence interval (CI), 0.40–5.57 ml/min/100 g on the diseased side; MD, 4.94 ml/min/100 g; 95% CI, 2.35–7.52 ml/min/100 g on the non-diseased side). Similar trends were observed for rCBF_S (MD, 3.98 ml/min/100 g; 95% CI, 2.30–5.67 ml/min/100 g on the diseased side; MD, 2.77 ml/min/100 g; 95% CI, 1.09–4.45 ml/min/100 g on the non-diseased side). Intraclass correlations 3 (ICC3s) between rCBF_N and rCBF_S were weak on the diseased side (ICC3, 0.25; 95% CI, -0.03–0.5; p = 0.07) and the non-diseased side (ICC3, 0.24; 95% CI, -0.05–0.5; p = 0.08). rCBF measurements based on this novel method were weakly correlated with rCBF measurements with SPECT.

烟雾病作为一种缺血性脑血管病，在血运重建后测量局部脑血流量 (rCBF) 至关重要。本研究旨在验证我们将近红外光谱 (NIRS) 与频率滤波器相结合以提取动脉成分的新技术。我们使用 NIRO-200NX (Hamamatsu Photonics, Japan) 和吲哚菁绿 (ICG) 在烟雾病血运重建前后以及手术结束时测量了 rCBF。rCBF 是使用 Fick 原理、动脉 ICG 浓度的变化和最大动脉 ICG 浓度计算的。将用 NIRS 测量的 rCBF (rCBF_N) 与用 SPECT 测量的术前和术后 rCBF (rCBF_S) 进行比较。分析了 34 个程序。rCBF_N 从基线到手术结束增加（平均差 (MD)，2.99 ml/min/100 g；95% 置信区间 (CI)，患病侧为 0.40–5.57 ml/min/100 g；MD，4.94 毫升/分钟/100 克；95% CI，2.35–7.52 ml/min/100 g（非患病侧）。rCBF_S 观察到类似的趋势（MD，3.98 ml/min/100 g；95% CI，2.30-5.67 ml/min/100 g 患病侧；MD，2.77 ml/min/100 g；95% CI，1.09 –4.45 ml/min/100 g（非病变侧）。rCBF_N 和 rCBF_S 之间的类内相关性 3 (ICC3s) 在患病侧较弱 (ICC3, 0.25; 95% CI, -0.03–0.5;p  = 0.07) 和非患病侧 (ICC3, 0.24; 95% CI, -0.05–0.5; p  = 0.08)。基于这种新方法的 rCBF 测量与 SPECT 的 rCBF 测量弱相关。