The expression of deoxythymidylate kinase (DTYMK) is up-regulated in liver cancer. However, the underlying biological function and potential mechanisms of DTYMK driving the progression of lung adenocarcinoma remains unclear. In this study, we investigated the role of DTYMK in lung adenocarcinoma and found that the expression of DTYMK in LUAD tissues was significantly higher than that of DTYMK expression in adjacent normal tissues. Kaplan-Meier survival analysis showed that patients with higher DTYMK expression correlated with adverse prognosis. ROC curve analysis showed that the AUC value of DTYMK was 0.914. Correlation analysis showed that DTYMK expression was associated with immune infiltration in LUAD. Finally, we determine that DTYMK regulated cell proliferation, cell migration, and cell cycle of lung adenocarcinoma in vitro. In conclusion, our data demonstrated that DTYMK was correlated with progression and immune infiltration, and could serve as a prognostic biomarker for lung adenocarcinoma.

中文翻译：

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综合分析DTYMK对肺腺癌患者免疫微环境评估、诊断及预后的影响

脱氧胸苷酸激酶 (DTYMK) 的表达在肝癌中上调。然而，DTYMK 驱动肺腺癌进展的潜在生物学功能和潜在机制仍不清楚。在本研究中，我们研究了 DTYMK 在肺腺癌中的作用，发现 DTYMK 在 LUAD 组织中的表达显着高于邻近正常组织中的 DTYMK 表达。Kaplan-Meier 生存分析表明，具有较高 DTYMK 表达的患者与不良预后相关。ROC曲线分析显示，DTYMK的AUC值为0.914。相关性分析表明，DTYMK 表达与 LUAD 中的免疫浸润有关。最后，我们确定 DTYMK 调节肺腺癌的细胞增殖、细胞迁移和细胞周期体外。总之，我们的数据表明 DTYMK 与进展和免疫浸润相关，可以作为肺腺癌的预后生物标志物。