Objectives. To investigate the effects of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) on liver function and immune function in patients with hepatocellular carcinoma (HCC). Methods. From December 2016 to January 2019, patients with primary liver cancer who could not be operated on were selected as the study subjects. 170 patients were randomly divided into two groups. The control group was treated with transcatheter arterial chemoembolization (n = 85). The patients in the observation group were treated with transcatheter arterial chemoembolization combined with radiofrequency ablation (n = 85). The clinical effects of the two groups were analyzed. The changes of liver function and immune function were detected by automatic biochemical analyzer before and after treatment. The changes of hypoxia inducible factor-1 (HIF1) alpha and vascular endothelial growth factor (VEGF) levels before and after treatment were analyzed by enzyme-linked immunosorbent assay (ELISA). Results. The total effective rate in the observation group was significantly higher than that in the control group (). After treatment, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), CD8+, HIF1 alpha, and VEGF decreased significantly (), while levels of total bilirubin, direct bilirubin, indirect bilirubin, CD3+, CD4+, and CD4+/CD8+ increased significantly (). The changes of the above indexes in the observation group were more significant than those in the control group (). Conclusion. Hepatic arterial chemoembolization combined with radiofrequency ablation has a significant effect on liver function and immune function in patients with liver cancer, which may be related to the abnormal levels of HIF1α and vascular endothelial growth factor.

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经导管动脉化疗栓塞联合射频消融对肝细胞癌患者肝功能及免疫功能的影响

目标。探讨经导管动脉化疗栓塞术（TACE）联合射频消融术（RFA）对肝细胞癌（HCC）患者肝功能和免疫功能的影响。方法。2016年12月至2019年1月，选择不能手术的原发性肝癌患者作为研究对象。170名患者被随机分为两组。对照组采用经导管动脉化疗栓塞治疗（n  = 85）。观察组患者采用经导管动脉化疗栓塞联合射频消融治疗（n = 85)。分析两组的临床疗效。治疗前后采用全自动生化分析仪检测肝功能和免疫功能的变化。采用酶联免疫吸附试验（ELISA）分析治疗前后缺氧诱导因子-1（HIF1）α和血管内皮生长因子（VEGF）水平的变化。结果。观察组总有效率显着高于对照组（）。治疗后，血清丙氨酸氨基转移酶 (ALT)、天冬氨酸氨基转移酶 (AST)、CD8+、HIF1 α 和 VEGF 水平显着下降。），而总胆红素、直接胆红素、间接胆红素、CD3+、CD4+和CD4+/CD8+水平显着增加（）。观察组上述指标变化较对照组更显着（）。 结论。肝动脉化疗栓塞联合射频消融对肝癌患者肝功能和免疫功能有显着影响，可能与HIF1α和血管内皮生长因子水平异常有关。