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Somatic mosaicism rewires transcriptional and epigenetic states in clonal hematopoiesis
Nature Genetics ( IF 31.7 ) Pub Date : 2022-09-26 , DOI: 10.1038/s41588-022-01181-1


Multi-modal single-cell sequencing enables mapping of mutant and wild-type human hematopoietic stem and progenitor cells within the same person, to define cellular phenotypic and epigenetic perturbations associated with clonal hematopoiesis.

中文翻译:

体细胞嵌合体重新连接克隆性造血中的转录和表观遗传状态

多模态单细胞测序能够对同一个人体内的突变型和野生型人类造血干细胞和祖细胞进行定位,以定义与克隆性造血相关的细胞表型和表观遗传扰动。
更新日期:2022-09-27
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