The present study aimed to investigate the antioxidant activity of Aniba canelilla (kunth) Mez (Lauraceae) essential oil (AcEO), exploring its potential for prevention and/or treatment of oxidative stress and associated inflammatory process. With this aim, Wistar rats (n = 6/group) were pre-treated intraperitoneally with saline (0.9%) or AcEO (2 or 5 mg/kg) for 5 days. One hour after the last dose, inflammation and oxidative stress were induced by carrageenan (0.3 mg/kg; ip.) administration. Total antioxidant capacity, reduced glutathione (GSH) and lipid peroxidation levels, protein concentration, and leukocyte migration were evaluated in peritoneal fluid. Lipid peroxidation was also evaluated in plasma. Carrageenan strongly reduced the peritoneal antioxidant capacity and GSH concentration, increasing peritoneal and plasma lipid peroxidation. It also promoted increased plasma leakage and leukocyte migration. Treatment with AcEO (2 and 5 mg/kg), whose major constituent was 1-nitro-2-phenylethane (77.5%), increased the peritoneal antioxidant capacity and GSH concentrations, and reduced lipid peroxidation, both peritoneal and plasma, thus inhibiting the carrageenan-induced oxidative imbalance. AcEO also reduced the carrageenan-induced plasma leakage and leukocyte migration. These data demonstrate the AcEO antioxidant activity and its ability to modulate plasma leakage and leukocyte migration, confirming its potential for treating diseases associated with inflammation and oxidative stress.

中文翻译：

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Aniba canelilla (Kunth) Mez (Lauraceae) 精油：对氧化应激和血管通透性的影响

本研究旨在研究Aniba canelilla (kunth) Mez (Lauraceae) 精油 (AcEO) 的抗氧化活性，探索其预防和/或治疗氧化应激和相关炎症过程的潜力。为了这个目标，Wistar 大鼠 ( n= 6/组）用盐水（0.9%）或 AcEO（2 或 5 mg/kg）腹膜内预处理 5 天。最后一次给药后一小时，角叉菜胶（0.3 mg/kg；ip.）给药诱导炎症和氧化应激。评估了腹膜液中的总抗氧化能力、还原型谷胱甘肽 (GSH) 和脂质过氧化水平、蛋白质浓度和白细胞迁移。还评估了血浆中的脂质过氧化。角叉菜胶强烈降低腹膜抗氧化能力和谷胱甘肽浓度，增加腹膜和血浆脂质过氧化。它还促进血浆渗漏和白细胞迁移增加。用主要成分为 1-硝基-2-苯乙烷 (77.5%) 的 AcEO（2 和 5 mg/kg）处理，增加了腹膜抗氧化能力和 GSH 浓度，并减少了脂质过氧化，腹膜和血浆，从而抑制角叉菜胶引起的氧化失衡。AcEO 还减少了角叉菜胶诱导的血浆渗漏和白细胞迁移。这些数据证明了 AcEO 的抗氧化活性及其调节血浆渗漏和白细胞迁移的能力，证实了其治疗与炎症和氧化应激相关的疾病的潜力。