Background

Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are incurable and expected to increase in prevalence in the upcoming decades. Environmental exposure to metals has been suggested as a contributing factor to the development of neurodegenerative disease. This systematic evidence map will identify and characterize the epidemiological and experimental data available on the intersection of eighteen metals of environmental concern (i.e., aluminum, antimony, arsenic, barium, beryllium, cadmium, chromium, cobalt, copper, lead, manganese, mercury, nickel, palladium, radium, silver, vanadium, and zinc) and three neurodegenerative disease clusters (i.e., tauopathies, synucleinopathies, and TDP-43 proteinopathies). We aim to describe the type and amount of evidence available (or lack thereof) for each metal and neurodegenerative disease combination and highlight important knowledge gaps and knowledge clusters for future research.

Methods

We will conduct a thorough search using two databases (MEDLINE and Web of Science Core Collection) and grey literature resources. Pre-defined criteria have been developed to identify studies which evaluate at least one of the selected metals and neurodegenerative disease-relevant outcomes (e.g., neuropathology, cognitive function, motor function, disease mortality). At each phase of review, studies will be evaluated by two reviewers. Studies determined to be relevant will be extracted for population, exposure, and outcome information. We will conduct a narrative review of the included studies, and the extracted data will be available in a database hosted on Tableau Public.

Conclusion

This protocol documents the decisions made a priori to data collection regarding these objectives.

中文翻译：

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环境暴露于金属和 tau 蛋白病、突触核蛋白病和 TDP-43 蛋白病的发展：系统证据图协议

背景

阿尔茨海默病、帕金森病和肌萎缩侧索硬化症等神经退行性疾病是无法治愈的，预计在未来几十年内患病率会增加。环境暴露于金属已被认为是神经退行性疾病发展的一个促成因素。这个系统的证据图将识别和描述 18 种环境关注金属（即铝、锑、砷、钡、铍、镉、铬、钴、铜、铅、锰、汞、镍、钯、镭、银、钒和锌）和三种神经退行性疾病簇（即 tau 蛋白病、突触核蛋白病和 TDP-43 蛋白病）。

方法

我们将使用两个数据库（MEDLINE 和 Web of Science 核心合集）和灰色文献资源进行彻底搜索。已经制定了预定义的标准来确定评估至少一种选定金属和神经退行性疾病相关结果（例如，神经病理学、认知功能、运动功能、疾病死亡率）的研究。在审查的每个阶段，研究将由两名审查员进行评估。将提取确定相关的研究以获取人群、暴露和结果信息。我们将对纳入的研究进行叙述性审查，提取的数据将在 Tableau Public 上托管的数据库中提供。

结论

该协议记录了关于这些目标的数据收集的先验决定。