Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China,International Journal of Hypertension

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Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China
International Journal of Hypertension ( IF 1.9 ) Pub Date : 2022-9-26 , DOI: 10.1155/2022/4632087
Xin He _{1,

2} , RuLin Ma ₁ , Yu Li ₁ , Haixia Wang ₁ , YiZhong Yan ₁ , YiDan Mao ₁ , ShengYu Liao ₁ , XueYing Sun ₁ , ShuXia Guo ₁ , Heng Guo _{1,

2}

Affiliation

Objective. This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. Then, we analyzed the effect of MTHFR 677C > T polymorphism on the association between the above miRNA and H-type hypertension. Method. In this study, the expression of miR-21, miR-29, and miR-199 was quantitatively measured in 120 serum samples and then stratified according to the C677T polymorphism to analyze the relationship between target miRNAs and HHcy. Results. The expression of miR-21/-29 in the hypertension group was higher than the normal group (). And the expression of miR-199 was higher in the hcy group than in the normal group (). In the CC and CT genotypes of MTHFR 677C > T, the expression of miR-21 was lower in the HHcy patients than in the normal individuals ( and ) and miR-199 was significantly higher in the HHcy patients than in the normal ones ( and ). No such difference was found in the TT genotype. Logistic regression analysis showed that after adjusting for sex, age, BMI, systolic blood pressure, diastolic blood pressure, and MTHFRC677 T gene polymorphism, miR-21 was negatively correlated with hcy (OR = 0.222, 95% CI (0.101–0.485), ) and miR-199 was positively correlated with hcy (OR = 1.823,95%CI (1.272∼2.614), ). Conclusion. miR-21, miR-29, and miR-199 are associated with H-type hypertension in the Kazakhs, especially hyperhomocysteinemia. And these three miRNAs may serve as biomarkers to provide clues to the potential pathogenesis of H-type hypertension.

更新日期：2022-09-26

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