Background. Gastric cancer (GC) belongs to a type of the most deadly cancer in the world, and the incidence rate of GC will increase in the coming decades. Tanshinone IIA (Tan IIA) is an active component that separated from Danshen. Tan IIA may also exert its therapeutic effects in disease with intestinal dysbacteriosis, at least partially, via regulating the intestinal microbiome. Nevertheless, it is obscure whether Tanshinone IIA affects the intestinal dysbacteriosis and plays antitumor roles. This research was designed to explore Tanshinone IIA potential on the intestinal dysbacteriosis of GC xenograft mice. Methods. Mouse xenograft GC tumor models were built and treated by Tan IIA. The tumor growth as well as microbiome in the intestinal were compared. Western blot was used to detect the phosphorylation of the NF-κB and expressions of the downstream cytokines IL-6 and IL-1β. Results. Microbiome in the intestinal was changed in xenograft tumor mice in comparison with the control mice. What is more, Tan IIA could influence the microbiome in the intestinal of the tumor mice. Tan IIA hinders the growth of xenograft tumor and change the microbiome in the intestinal, but intestinal dysbacteriosis condition partially blocked Tan IIA-stimulated antitumor effects. In addition, intestinal dysbacteriosis abrogated Tan IIA-stimulated decrease in the NF-κB signaling in xenograft tumor mice. Conclusions. Tanshinone IIA may inhibit GC tumor growth via affecting the intestinal microbiome through regulating the NF-κB signaling.

中文翻译：

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丹参酮 IIA 可能通过影响肠道微生物群抑制胃癌


背景。胃癌（GC）属于世界上最致命的癌症之一，未来几十年GC的发病率将会增加。丹参酮 IIA (Tan IIA) 是从丹参中分离出来的活性成分。 Tan IIA 还可能通过调节肠道微生物组发挥其对肠道菌群失调疾病的治疗作用，至少部分如此。然而，丹参酮 IIA 是否影响肠道菌群失调并发挥抗肿瘤作用尚不清楚。本研究旨在探讨丹参酮 IIA 对 GC 异种移植小鼠肠道菌群失调的潜力。方法。 Tan IIA 建立并治疗了小鼠异种移植 GC 肿瘤模型。比较肿瘤生长以及肠道微生物组。 Western blot检测NF- κB的磷酸化及下游细胞因子IL-6、IL- 1β的表达。结果。与对照小鼠相比，异种移植肿瘤小鼠的肠道微生物组发生了变化。更重要的是，Tan IIA 可以影响肿瘤小鼠肠道中的微生物组。 Tan IIA 阻碍异种移植肿瘤的生长并改变肠道微生物组，但肠道菌群失调状况部分阻碍了 Tan IIA 刺激的抗肿瘤作用。此外，肠道菌群失调消除了 Tan IIA 刺激的异种移植肿瘤小鼠中 NF- κ B 信号传导的减少。结论。 Tanshinone IIA 可能通过调节 NF- κ B 信号传导影响肠道微生物组来抑制 GC 肿瘤生长。