Purpose. This work is aimed at determining the application value of platelet-rich plasma (PRP) therapy plus total knee arthroplasty (TKA) in traumatic arthritis (TA) of the knee. Methods. A retrospective study was conducted on 78 cases of TA of the knee admitted between March 2021 and January 2022 to the Quanzhou First Hospital Affiliated to Fujian Medical University. Based on different treatment methods, 38 cases treated with TKA were assigned to the control group, and 40 cases intervened by PRP+TKA were included in the observation group. The operation time (OT), drainage volume (DV), total blood loss (TBL), incision inflammatory reaction rate, and grade A healing rate were recorded. Besides, preoperative and postoperative knee joint Hospital for Special Surgery (HSS) scores, knee joint pain assessed by visual analogue scale (VAS), knee joint range of motion (ROM), and bone metabolism parameters (osteocalcin (OST), total N-terminal propeptide of type I procollagen (tPINP), and β-isomerized C-terminal telopeptides (β-CTX)) were recorded. Results. The observation group showed reduced postoperative DV and TBL than the control group (). The two cohorts differed insignificantly in OT, incision inflammatory response rate, and grade A healing rate (). The observation group also had better improvement in the HSS score, pain VAS score, and knee ROM (). And higher postoperative OST and tPINP levels while lower β-CTX were determined in the observation group (). Conclusions. PRP+TKA can validly improve the levels of bone metabolism markers in patients with TA of the knee and promote their knee functional recovery, with favorable safety.

中文翻译：

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全膝关节置换术联合富血小板血浆治疗创伤性膝关节炎的应用价值


目的。本工作旨在确定富血小板血浆（PRP）疗法联合全膝关节置换术（TKA）在膝关节创伤性关节炎（TA）中的应用价值。方法。对2021年3月至2022年1月福建医科大学附属泉州第一医院收治的78例膝关节TA患者进行回顾性研究。根据治疗方法的不同，将38例行TKA治疗的患者纳入对照组，40例行PRP+TKA干预的患者纳入观察组。记录手术时间（OT）、引流量（DV）、总失血量（TBL）、切口炎症反应率、A级愈合率。此外，术前术后膝关节特殊外科医院（HSS）评分、膝关节疼痛视觉模拟评分（VAS）、膝关节活动度（ROM）、骨代谢参数（骨钙素（OST）、总N-记录了 I 型原胶原末端前肽 (tPINP) 和β异构化 C 末端端肽 ( β -CTX)。结果。观察组术后 DV 和 TBL 较对照组降低（）。两个队列在 OT、切口炎症反应率和 A 级愈合率方面无显着差异（）。观察组在 HSS 评分、疼痛 VAS 评分和膝关节 ROM 方面也有更好的改善（）。观察组术后 OST 和 tPINP 水平较高，而β -CTX 水平较低（）。结论。 PRP+TKA可有效改善膝关节TA患者骨代谢标志物水平，促进膝关节功能恢复，且安全性良好。