ABSTRACT

Candida auris has emerged globally as a multidrug-resistant pathogen causing outbreaks in health care facilities. Whole genome sequencing (WGS) analysis has identified four major clades, while earlier WGS data from a single Iranian isolate suggested the existence of a potential fifth clade. Here, we confirm the existence of this fifth clade by providing WGS data of another four Iranian isolates. These clade V isolates differed less than 100 single-nucleotide polymorphisms (SNPs) between each other, while they were separated from the other clades by more than 200,000 SNPs. Two of these isolates were resistant to fluconazole and were found to harbour mutations in the TAC1b and ERG11 genes.

摘要

耳念珠菌作为一种多重耐药病原体已在全球范围内出现，导致卫生保健机构爆发。全基因组测序 (WGS) 分析已经确定了四个主要进化枝，而早期来自一个伊朗分离株的 WGS 数据表明存在潜在的第五个进化枝。在这里，我们通过提供另外四个伊朗分离株的 WGS 数据来确认这第五个进化枝的存在。这些进化枝 V 分离株彼此之间的单核苷酸多态性 (SNP) 差异不到 100 个，而它们与其他进化枝的分离超过 200,000 个 SNP。其中两个分离株对氟康唑具有抗药性，并被发现在TAC1b和ERG11基因中存在突变。