Aerosol inhalation delivery of ceftriaxone in mice was investigated. An ultrasonic nebulizer within the ranges of mean particle diameter 0.5–1.5 μm and mass concentration 0.01–0.6 μg/cm³ was used in inhalation experiments. Pharmacokinetic measurements were carried out using a nose-only chamber. Ceftriaxone concentration in blood serum and its mass in the lungs of mice were measured as a function of time using high-performance liquid chromatography. The body-delivered dose was within the range 3–5 mg/kg. The antibacterial effect of aerosolized ceftriaxone was investigated for mice infected with Klebsiella pneumoniae 82 and Staphylococcus aureus ATCC 25 953. The survival rate for infected mice after the treatment with ceftriaxone aerosol revealed the high antibacterial efficiency of this kind of treatment.

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头孢曲松在小鼠体内的气溶胶吸入给药：生成程序、药代动力学和治疗结果

研究了头孢曲松在小鼠中的气溶胶吸入递送。吸入实验使用平均粒径0.5~1.5 μm、质量浓度0.01~0.6 μg/cm ^{3范围内的超声雾化器。}使用仅鼻腔进行药代动力学测量。使用高效液相色谱法测量血清中的头孢曲松浓度及其在小鼠肺中的质量随时间的变化。体内给药剂量在 3-5 mg/kg 范围内。研究了雾化头孢曲松对感染肺炎克雷伯菌82 和金黄色葡萄球菌的小鼠的抗菌作用ATCC 25 953. 感染小鼠经头孢曲松气雾剂治疗后的存活率显示出这种治疗的高抗菌效率。