Proton pump inhibitors (PPIs) are widely prescribed and are indicated for the treatment of several gastrointestinal disorders. Allergists may prescribe PPIs as a result of the coincidence of gastroesophageal reflux disease with asthma or rhinitis, or when gastroesophageal reflux disease presents as chronic cough. Furthermore, long-term, high-dose PPI therapy is a recommended option for managing eosinophilic esophagitis, resulting in histologic remission in approximately 40% of patients. Here, we discuss current recommendations for PPI use, its deescalation, and its side effect profile. We review evidence supporting the epidemiologic link between the use of acid-suppressant medication and the subsequent development of allergic disorders.

质子泵抑制剂(PPI) 被广泛用于治疗多种胃肠道疾病。由于胃食管反流病同时患有哮喘或鼻炎，或者当胃食管反流病表现为慢性咳嗽时，过敏科医生可能会开出 PPI。此外，长期、大剂量 PPI 治疗是治疗嗜酸性粒细胞性食管炎的推荐选择，可使约 40% 的患者获得组织学缓解。在这里，我们讨论 PPI 使用的当前建议、其降级及其副作用概况。我们回顾了支持使用抑酸药物与随后发生过敏性疾病之间流行病学联系的证据。