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Dihydroquercetin composite nanofibrous membrane prevents UVA radiation-mediated inflammation, apoptosis and oxidative stress by modulating MAPKs/Nrf2 signaling in human epidermal keratinocytes
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2022-09-23 , DOI: 10.1016/j.biopha.2022.113727
Jinping Zhang 1 , Yongchun Zheng 2 , Bo Hong 1 , Lina Ma 2 , Yingchun Zhao 1 , Shuai Zhang 1 , Shuwen Sun 1 , Qiteng Ding 1 , Yue Wang 1 , Wencong Liu 1 , Chuanbo Ding 2
Affiliation  

Exposure to ultraviolet (UV) radiation is a key cause of skin inflammation and photodamage in the environment. Dihydroquercetin composite nanofiber membrane (CPD) is a nano-scale membrane cloth prepared by electrospinning technology. The results in this study showed that CPD could enhance the activities of endogenous antioxidant enzymes such as SOD and GSH-Px induced by UVA radiation, and reduce the overexpression of ROS. MAPKs/Nrf2 signaling is associated with inflammation, apoptosis and oxidative stress. Compared with control HaCaT cells, we found that CPD pretreatment prevents MAPK (p-ERK, p-JNK, and p-P38)/Nrf2-induced inflammation, apoptosis, and oxidative stress signaling during UVA exposure pathway overexpression. Immunofluorescence experiments also showed that CPD could reduce the fluorescence intensity of Caspase-3 and TNF-α. These results suggest that CPD may be a successful healing agent that provides reinforcement against UVA-induced oxidative and irritating skin compensation.



中文翻译:

二氢槲皮素复合纳米纤维膜通过调节人表皮角质形成细胞中的 MAPKs/Nrf2 信号传导来预防 UVA 辐射介导的炎症、细胞凋亡和氧化应激

暴露于紫外线 (UV) 辐射是环境中皮肤发炎和光损伤的主要原因。二氢槲皮素复合纳米纤维膜(CPD)是一种采用静电纺丝技术制备的纳米级膜布。本研究结果表明,CPD可以增强UVA辐射诱导的SOD、GSH-Px等内源性抗氧化酶的活性,减少ROS的过表达。MAPKs/Nrf2 信号传导与炎症、细胞凋亡和氧化应激有关。与对照 HaCaT 细胞相比,我们发现 CPD 预处理可防止 MAPK(p-ERK、p-JNK 和 p-P38)/Nrf2 在 UVA 暴露途径过表达期间诱导的炎症、细胞凋亡和氧化应激信号传导。免疫荧光实验还表明,CPD 可以降低 Caspase-3 和 TNF-α 的荧光强度。

更新日期:2022-09-23
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