Inspiration to mRNA-based COVID-19 vaccination: Serious adverse case reports with hepatitis B vaccine in real-world,Frontiers in Pediatrics

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Inspiration to mRNA-based COVID-19 vaccination: Serious adverse case reports with hepatitis B vaccine in real-world
Frontiers in Pediatrics ( IF 2.1 ) Pub Date : 2022-09-23 , DOI: 10.3389/fped.2022.888686
Jinmiao Lu ₁ , Xunjie Zhang ₁ , Hong Xu ₂ , Zhiping Li ₂

Affiliation

Objectives

The hepatitis B vaccine comprises hepatitis B surface antigen (HBsAg) produced by transgenic yeast cells. There are few serious adverse events (SAE) reports after Hepatitis B vaccination.

Methods

The authors searched the Chinese legal documents database for all SAE with Hepatitis B vaccination from January 2010 to January 2022.

Results

All seven patients received yeast-derived recombinant hepatitis B vaccine. Three cases of myocarditis (death), 2 cases of interstitial pneumonia (death), and 2 cases of encephalitis. The mean time of onset of SAE was 8.3 ± 4.3 h after vaccination.

Conclusion

The mechanism of vaccine-induced myocarditis may come from immune protein reactions. Based on the experience of Hepatitis B vaccine adverse events, we present new insights into the mechanism of myocarditis caused by the COVID-19 vaccine.

更新日期：2022-09-23

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