Genome-wide association studies have identified hundreds of robust genetic associations underlying psychiatric disorders and provided important biological insights into disease onset and progression. There is optimism that genetic findings will pave the way to precision psychiatry by facilitating the development of more effective treatments and the identification of groups of patients that these treatments should be targeted toward. However, there are several challenges that must be addressed before genetic findings can be translated into the clinic. In this Perspective, we highlight ten challenges for the field of psychiatric genetics, focused on the robust and generalizable detection of genetic risk factors, improved definition and assessment of psychopathology and achieving better clinical indicators. We discuss recent advancements in the field that will improve the explanatory and predictive power of genetic data and ultimately contribute to improving the management and treatment of patients with a psychiatric disorder.

全基因组关联研究已经确定了数百种潜在的精神疾病强大的遗传关联，并为疾病的发作和进展提供了重要的生物学见解。人们乐观地认为，通过促进更有效的治疗方法的开发和确定这些治疗应针对的患者群体，遗传学研究结果将为精准精神病学铺平道路。然而，在将遗传发现转化为临床之前，必须解决几个挑战。在这个观点中，我们强调了精神病遗传学领域的十大挑战，重点是对遗传风险因素进行稳健和普遍的检测，改进精神病理学的定义和评估，以及实现更好的临床指标。