Concerns over climate change and environmental pollution resulting from petroleum refining has spurred the exploitation of green replacements for producing chemicals and fuels. Valorization of lignocellulosic biomass into chemicals represents a promising alternative to petroleum refining. Biological and chemical catalysis are two leading routes for lignocellulose variolization, but strategies relying simply on biological or chemical conversion have shown limitations. Integrating biocatalysts with chemocatalysts could leverage the inherent strengths of both while circumventing their respective disadvantages, benefiting product yield and selectivity, and reducing cost and waste generation. This review focuses on the coupled chemocatalytic and biocatalytic synthesis of renewable chemicals from polysaccharides and their derived platform chemicals. In addition, strategies for producing value-added products from lignin via integrated chemical depolymerization and biological conversion are highlighted. The techno-economics of integrating chemocatalysts and biocatalysts in producing chemicals in the context of biorefinery are also discussed. Finally, perspectives on designing integrated chemical and biological catalysis for renewable chemicals production are provided. © 2022 Society of Chemical Industry (SCI).

中文翻译：

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综合化学和生物催化过程：从木质纤维素生物质生产可再生化学品的新方式

对石油精炼造成的气候变化和环境污染的担忧刺激了开发绿色替代品来生产化学品和燃料。将木质纤维素生物质价值化为化学品是石油精炼的一种有前途的替代方法。生物和化学催化是木质纤维素 variolization 的两条主要途径，但仅依靠生物或化学转化的策略显示出局限性。将生物催化剂与化学催化剂整合可以利用两者的内在优势，同时规避各自的缺点，有利于产品收率和选择性，并降低成本和废物产生。本综述侧重于从多糖及其衍生平台化学品中耦合化学催化和生物催化合成可再生化学品。此外，重点介绍了通过综合化学解聚和生物转化从木质素生产增值产品的策略。还讨论了在生物精炼厂的背景下整合化学催化剂和生物催化剂生产化学品的技术经济学。最后，提供了设计用于可再生化学品生产的综合化学和生物催化的观点。© 2022 化学工业协会 (SCI)。提供了设计用于可再生化学品生产的综合化学和生物催化的观点。© 2022 化学工业协会 (SCI)。提供了设计用于可再生化学品生产的综合化学和生物催化的观点。© 2022 化学工业协会 (SCI)。