Gastric cancer (GC) is the fifth most common cancer worldwide and the third most fatal. Cancer-associated fibroblasts (CAFs) play an essential role in promoting the occurrence and development of gastric cancer in all stages. NFYB is highly expressed in multiple tumors and promotes tumor invasion, metastasis, and drug resistance, but its role in the occurrence and development of gastric cancer remains unclear. Hence, we used TCGA, TIMER, Kaplan-Meier Plot, and UALCAN databases to analyze the expression of NFYB in pan-cancers and assess its clinical prognostic value. We found that high expression of NFYB may be a promising prognostic biomarker in patients with gastric cancer. High expression of NFYB was associated with high T stage, high histological grade, diffuse gastric cancer, and early-onset GC. Moreover, High expression of NFYB was associated with CAFs infiltration in the GC microenvironment. The prognosis of GC patients with high expression of NFYB and high infiltration of CAFs was worse. Therefore, NFYB may serve as a potential prognostic biomarker in patients with GC.

中文翻译：

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NFYB 的过度表达影响基质细胞重编程并预测胃癌患者的生存率较差

胃癌 (GC) 是全球第五大常见癌症，也是第三大致命癌症。癌相关成纤维细胞（cancer-associated fibroblasts，CAFs）在胃癌各阶段的发生发展过程中起着至关重要的促进作用。NFYB在多种肿瘤中高表达，促进肿瘤侵袭、转移和耐药，但其在胃癌发生发展中的作用尚不清楚。因此，我们使用 TCGA、TIMER、Kaplan-Meier Plot 和 UALCAN 数据库来分析 NFYB 在泛癌中的表达并评估其临床预后价值。我们发现 NFYB 的高表达可能是胃癌患者有前景的预后生物标志物。NFYB 的高表达与高 T 分期、高组织学分级、弥漫性胃癌和早发性胃癌相关。而且，NFYB 的高表达与 GC 微环境中的 CAF 浸润有关。NFYB高表达、CAFs高浸润的GC患者预后较差。因此，NFYB 可作为 GC 患者潜在的预后生物标志物。