We explored the effects of an oral health intervention on the oral microbiome and cognitive function of patients with mild Alzheimer's disease (AD) and determined the influence on disease progression. Sixty-six patients with mild AD were randomly assigned to intervention or control groups and received a 24-week oral health intervention and routine care, respectively. Data were collected at baseline and week 24. 16 S rRNA sequencing was used to analyze oral microbiota. After 24 weeks of oral health intervention, Kayser-Jones Brief Oral Health Status Examination (BOHSE), Mini-Mental State Examination (MMSE), Neuropsychiatric Inventory (NPI), Nursing Home Adjustment Scale (NHAS), and Alzheimer's Disease Cooperative Study-ADL (ADCS-ADL) scores were different between groups (p < 0.05). Subgingival plaque in patients with AD showed significant differences in the diversity and abundance of oral microbiomes, with a higher abundance of normal oral flora in the intervention group. We found oral health intervention strategies are effective in modifying subgingival microbiota differences and slowing cognitive decline in mild AD patients.

我们探讨了口腔健康干预对轻度阿尔茨海默病 (AD) 患者口腔微生物组和认知功能的影响，并确定了对疾病进展的影响。66 名轻度 AD 患者被随机分配到干预组或对照组，分别接受为期 24 周的口腔健康干预和常规护理。在基线和第 24 周收集数据。使用 16 S rRNA 测序分析口腔微生物群。经过24周的口腔健康干预，Kayser-Jones Brief Oral Health Status Examination (BOHSE), Mini-Mental State Examination (MMSE), Neuropsychiatric Inventory (NPI), Nursing Home Adjustment Scale (NHAS), and Alzheimer's Disease Cooperative Study-ADL (ADCS-ADL) 分数在组间不同 ( p < 0.05)。AD 患者的龈下菌斑在口腔微生物组的多样性和丰度方面表现出显着差异，干预组的正常口腔菌群丰度更高。我们发现口腔健康干预策略可有效改变轻度 AD 患者的龈下微生物群差异和减缓认知能力下降。