Parkinson's disease is the second most prevalent neurodegenerative disease after Alzheimer's disease, mostly happened in the elder population and the prevalence gradually increased with age. Parkinson’s disease is a movement disorder that severely affects patients’ daily life. The mechanism of Parkinson’s disease still remains unknown, however, studies already proved that the damage or absence of dopaminergic neurons located in the substantia nigra and the decreased dopamine in the striatum are significantly related to Parkinson’s disease. To date, the mainstream treatment of Parkinson's disease has been achieved by alleviating its associated morbid symptoms, such as the use of levodopa, carbidopa, dopamine receptor agonists, monoamine oxidase type B inhibitors, anticholinergic drugs, etc. However, strong side effects, even toxicity, have been reported after using these drugs, with reduced effectiveness over time. Plant compounds have shown good therapeutic effects in neurodegenerative diseases as a less toxic treatment. In this review, we have compiled several natural plant compounds and classified the currently reported compounds for therapeutic use based on their structural parent nuclei and constituent elements. We wish to inspire new ideas for the treatment of Parkinson's disease by summarizing their mechanisms.

帕金森病是继阿尔茨海默病之后第二大流行的神经退行性疾病，多发生在老年人群中，随着年龄的增长患病率逐渐增加。帕金森病是一种严重影响患者日常生活的运动障碍。帕金森病的发病机制尚不清楚，但已有研究证明，位于黑质的多巴胺能神经元的损伤或缺失以及纹状体中多巴胺的减少与帕金森病有显着的相关性。迄今为止，帕金森病的主流治疗是通过减轻其相关的病态症状实现的，如使用左旋多巴、卡比多巴、多巴胺受体激动剂、单胺氧化酶B型抑制剂、抗胆碱能药物等。毒性，在使用这些药物后有报道，随着时间的推移效果会降低。植物化合物作为一种毒性较小的治疗方法，在神经退行性疾病中显示出良好的治疗效果。在这篇综述中，我们整理了几种天然植物化合物，并根据它们的结构母核和组成元素对目前报道的用于治疗用途的化合物进行了分类。我们希望通过总结其机制来激发治疗帕金森病的新思路。我们汇编了几种天然植物化合物，并根据其结构母核和组成元素对目前报道的用于治疗用途的化合物进行分类。我们希望通过总结其机制来激发治疗帕金森病的新思路。我们汇编了几种天然植物化合物，并根据其结构母核和组成元素对目前报道的用于治疗用途的化合物进行分类。我们希望通过总结其机制来激发治疗帕金森病的新思路。