The metabotropic γ-aminobutyric acid type B receptor (GABA_BR) remains a hotspot in the recent research area. Being an idiosyncratic G-protein coupled receptor family member, the GABA_BR manifests adaptively tailored functionality under multifarious modulations by a constellation of agents, pointing to cross-talk between receptors and effectors that converge on the domains of mood and memory. This review systematically summarizes the latest achievements in signal transduction mechanisms of the GABA_BR-effector-regulator complex and probes how the up-and down-regulation of membrane-delimited GABA_BRs are associated with manifold intrinsic and extrinsic agents in synaptic strength and plasticity. Neuropsychiatric conditions depression and addiction share the similar pathophysiology of synapse inadaptability underlying negative mood-related processes, memory formations, and impairments. In the attempt to emphasize all convergent discoveries, we hope the insights gained on the GABA_BR system mechanisms of action are conducive to designing more therapeutic candidates so as to refine the prognosis rate of diseases and minimize side effects.

代谢型γ-氨基丁酸B型受体（GABA _B R）仍然是近期研究领域的热点。作为一个特异的 G 蛋白偶联受体家族成员，GABA _B R 在一系列药剂的多种调制下表现出适应性定制的功能，这表明受体和效应器之间的串扰集中在情绪和记忆领域。本综述系统总结了GABA _{B R-效应-调节复合物信号转导机制的最新研究成果，探讨了膜界GABA B}的上调和下调机制。Rs 与突触强度和可塑性方面的多种内在和外在因素有关。神经精神疾病抑郁和成瘾具有相似的突触不适应的病理生理学，这些病理生理学是消极情绪相关过程、记忆形成和损伤的基础。为了强调所有趋同的发现，我们希望对 GABA _B R 系统作用机制的见解有助于设计更多的治疗候选者，从而提高疾病的预后率并最大限度地减少副作用。