当前位置: X-MOL 学术Biomed. Pharmacother. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Molecular consequences of the exposure to toxic substances for the endocrine system of females
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2022-09-21 , DOI: 10.1016/j.biopha.2022.113730
Alicja Kowalczyk 1 , Marcjanna Wrzecińska 2 , Ewa Czerniawska-Piątkowska 2 , José Pedro Araújo 3 , Przemysław Cwynar 1
Affiliation  

Endocrine-disrupting chemicals (EDCs) are common in the environment and in everyday products such as cosmetics, plastic food packaging, and medicines. These substances are toxic in small doses (even in the order of micrograms) and enter the body through the skin, digestive or respiratory system. Numerous studies confirm the negative impact of EDCs on living organisms. They disrupt endocrine functions, contributing to the development of neoplastic and neurological diseases, as well as problems with the circulatory system and reproduction. EDCs affect humans and animals by modulating epigenetic processes that can lead to disturbances in gene expression or failure and even death. They also affect steroid hormones by binding to their receptors as well as interfering with synthesis and secretion of hormones. Prenatal exposure may be related to the impact of EDCs on offspring, resulting in effects of these substances on the ovaries and leading to the reduction of fertility through disturbances in the function of steroid receptors or problems with steroidogenesis and gametogenesis. Current literature indicates the need to continue research on the effects of EDCs on the female reproductive system. The aim of this review was to identify the effects of endocrine-disrupting chemicals on the female reproductive system and their genetic effects based on recent literature.



中文翻译:

女性内分泌系统接触有毒物质的分子后果

内分泌干​​扰化学品 (EDC) 在环境和日常用品中很常见,例如化妆品、塑料食品包装和药品。这些物质在小剂量(甚至微克量级)时是有毒的,并通过皮肤、消化系统或呼吸系统进入人体。大量研究证实了 EDC 对生物体的负面影响。它们破坏内分泌功能,导致肿瘤和神经系统疾病的发展,以及循环系统和生殖问题。EDCs 通过调节表观遗传过程影响人类和动物,这些过程可能导致基因表达紊乱或失败甚至死亡。它们还通过与其受体结合以及干扰激素的合成和分泌来影响类固醇激素。产前暴露可能与 EDCs 对后代的影响有关,导致这些物质对卵巢的影响,并通过类固醇受体功能紊乱或类固醇生成和配子生成问题导致生育力下降。目前的文献表明需要继续研究 EDC 对女性生殖系统的影响。本综述的目的是根据最近的文献确定内分泌干扰化学品对女性生殖系统的影响及其遗传影响。目前的文献表明需要继续研究 EDC 对女性生殖系统的影响。本综述的目的是根据最近的文献确定内分泌干扰化学品对女性生殖系统的影响及其遗传影响。目前的文献表明需要继续研究 EDC 对女性生殖系统的影响。本综述的目的是根据最近的文献确定内分泌干扰化学品对女性生殖系统的影响及其遗传影响。

更新日期:2022-09-22
down
wechat
bug