One premise of cancer treatment is that if a tumour is cut out but tumour cells remain present or close to the edges (of the cut), the risk of cancer returning at the same site is increased. Increased surgical focus on adequacy of margin excision would improve breast cancer survival worldwide. In many cancers, such as colorectal cancer, attention to ensuring meticulous removal of the cancer with an encompassing cuff of normal tissue (ie, no tumour at the pathological margin) results in improved outcomes. The association between margin involvement and poorer recurrence and survival outcomes12 led to studies that showed a strong association between the width of tumour from the margin in colorectal cancer and subsequent outcomes.2 Most patients with early breast cancer are treated with breast conserving surgery. Removing cancers without leaving malignant cells at a surgical margin reduces local recurrence34567 but the effects of margin involvement on distant recurrence and mortality are unclear. How far the tumour should be from the specimen margin to ensure optimum oncological outcomes is contentious. When cancer is surgically removed, the tumour is subject to pathological examination. The edges of the removed cancer specimens, known as the margins, can be either microscopically involved, in that the tumour is at the edge of the specimen, or not involved, that is, no tumour is seen at the edge. The distance …

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浸润性乳腺癌保乳术后切缘宽度及远处复发及生存率

癌症治疗的一个前提是，如果肿瘤被切除，但肿瘤细胞仍然存在或靠​​近（切口的）边缘，那么癌症在同一部位复发的风险就会增加。增加对边缘切除充分性的手术关注将提高全世界乳腺癌的存活率。在许多癌症中，例如结直肠癌，注意确保用正常组织的环绕袖带（即病理边缘没有肿瘤）仔细切除癌症会导致改善的结果。切缘受累与较差的复发和生存结果之间的关联 12 导致研究表明，结直肠癌切缘的肿瘤宽度与后续结果之间存在密切关联。 2 大多数早期乳腺癌患者接受保乳手术治疗。切除癌症而不在手术切缘留下恶性细胞可减少局部复发 34567，但切缘受累对远处复发和死亡率的影响尚不清楚。肿瘤应该离标本边缘多远才能确保最佳的肿瘤学结果是有争议的。当通过手术切除癌症时，对肿瘤进行病理学检查。切除的癌症标本的边缘，称为边缘，可以在显微镜下受累，即肿瘤位于标本的边缘，也可以不受累，即在边缘看不到肿瘤。距离 … 肿瘤应该离标本边缘多远才能确保最佳的肿瘤学结果是有争议的。当通过手术切除癌症时，对肿瘤进行病理学检查。切除的癌症标本的边缘，称为边缘，可以在显微镜下受累，即肿瘤位于标本的边缘，也可以不受累，即在边缘看不到肿瘤。距离 … 肿瘤应该离标本边缘多远才能确保最佳的肿瘤学结果是有争议的。当通过手术切除癌症时，对肿瘤进行病理学检查。切除的癌症标本的边缘，称为边缘，可以在显微镜下受累，即肿瘤位于标本的边缘，也可以不受累，即在边缘看不到肿瘤。距离 …