Perchlorate, nitrate, and thiocyanate are reported to affect human health. However, it is unclear about the associations between exposure to these chemicals and abdominal aortic calcification (AAC). A total of 959 individuals were included in a large representative survey. Urinary levels of perchlorate, nitrate, and thiocyanate were measured by ion chromatography coupled with electrospray tandem mass spectrometry. AAC was diagnosed based on dual-energy X-ray absorptiometry (DXA). There were 276 (28.8%) cases of AAC among the participants. The level of urinary nitrate was significantly lower in AAC patients compared with non-AAC patients (36.4 mg/L [20.6, 59.5] vs. 42.4 [23.8, 68.3]; P = 0.013). In multivariable-adjusted logistic regression models, urinary nitrate was associated with the prevalence of AAC. Compared with the lowest quartile, the odds ratios (95% confidence intervals) across increasing quartiles were 1.06 (0.69–1.61; P = 0.799), 0.64 (0.41–1.00; P = 0.049) and 0.74 (0.47–1.15; P = 0.180). Restricted cubic splines suggested that urinary nitrate ranging between 43.7 and 115.4 mg/L was associated with a lower risk of AAC. Moderate exposure to nitrate was associated with a lower risk of AAC.

据报道，高氯酸盐、硝酸盐和硫氰酸盐会影响人体健康。然而，尚不清楚接触这些化学物质与腹主动脉钙化 (AAC) 之间的关联。共有 959 人参与了一项大型代表性调查。高氯酸盐、硝酸盐和硫氰酸盐的尿液水平通过离子色谱法与电喷雾串联质谱联用来测量。AAC 的诊断基于双能 X 射线吸收测定法 (DXA)。参与者中有 276 例 (28.8%) AAC 病例。与非 AAC 患者相比，AAC 患者的尿硝酸盐水平显着降低（36.4 mg/L [20.6, 59.5] vs. 42.4 [23.8, 68.3]；P= 0.013）。在多变量调整后的逻辑回归模型中，尿硝酸盐与 AAC 的患病率相关。与最低四分位数相比，增加四分位数的比值比（95% 置信区间）分别为 1.06（0.69–1.61；P = 0.799）、0.64（0.41–1.00；P = 0.049）和 0.74（0.47–1.15；P = 0.180 ） ). 受限三次样条表明，尿硝酸盐浓度在 43.7 至 115.4 mg/L 之间与 AAC 风险较低相关。适度接触硝酸盐与较低的 AAC 风险相关。