There is growing evidence that lncRNAs play an important role in the progression of HCC, especially liver-specific expression of lncRNAs. LINC02428 is a liver-specific labeled lncRNA, but its role in HCC is unclear. We investigated the expression characteristics of LINC02428 in hepatocellular carcinoma tissues and analyzed its function in HCC. Using TCGA public data we found that the expression level of LINC02428 was significantly reduced in hepatocellular carcinoma tissues, compared to normal tissues. LINC02428 was also significantly reduced in hepatocellular carcinoma tissues in our cDNA microarray data from HCC patients. Survival analysis suggests that HCC patients with lower LINC02428 have a lower overall survival rate. In an in vitro analysis, overexpression of LINC02428 inhibited HCC cell proliferation, migration, and induced apoptosis. In conclusion, we report for the first time the expression profile of a liver-specific lncRNA, LINC02428, in HCC and confirmed its ability to inhibit the progression of HCC. LINC02428 may become a new target for the diagnosis and treatment of HCC.

中文翻译：

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LINC02428，一种肝脏特异性长非编码 RNA 抑制肝细胞癌进展

越来越多的证据表明 lncRNA 在 HCC 的进展中发挥重要作用，尤其是 lncRNA 的肝脏特异性表达。LINC02428 是一种肝脏特异性标记的 lncRNA，但其在 HCC 中的作用尚不清楚。我们研究了 LINC02428 在肝细胞癌组织中的表达特征，并分析了其在 HCC 中的功能。使用 TCGA 公开数据，我们发现与正常组织相比，肝细胞癌组织中 LINC02428 的表达水平显着降低。在我们来自 HCC 患者的 cDNA 微阵列数据中，LINC02428 在肝细胞癌组织中也显着减少。生存分析表明，具有较低 LINC02428 的 HCC 患者的总生存率较低。在体外分析中，LINC02428 的过表达抑制 HCC 细胞增殖、迁移和诱导细胞凋亡。总之，我们首次报道了肝脏特异性 lncRNA LINC02428 在 HCC 中的表达谱，并证实了其抑制 HCC 进展的能力。LINC02428可能成为HCC诊断和治疗的新靶点。