Association between snoring and insulin levels in the US population: a cross-sectional study,Sleep and Breathing

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Association between snoring and insulin levels in the US population: a cross-sectional study
Sleep and Breathing ( IF 2.1 ) Pub Date : 2022-09-22 , DOI: 10.1007/s11325-022-02709-9
Kun Wang ₁ , Xuzhong Hu ₁ , Ziao Li ₁ , Michael Smolinski ₂ , Wenjie Xiao ₁ , Jinshen He ₁

Affiliation

Purpose

Snoring may cause a number of problems such as tiredness, obesity, and even severe diseases, but the correlation between snoring and insulin secretion, which has important clinical significance, has rarely been studied. The objective of this study was to evaluate the correlation between snoring frequency and insulin secretion and discuss the potential mechanisms, thereby estimating the health condition of β-cells of individuals who snore.

Methods

The analyses used data from National Health and Nutrition Examination Survey (NHANES) from 2015 to 2018. A regression analysis was performed for snoring frequency and insulin concentration, and then multiple regression analyses excluded various factors related to insulin secretion, including age, sex, race, body mass index (BMI), factors indicating patients’ nutritional condition, and symptoms possibly implying obstructive sleep apnea. Subsequently, three hierarchical multiple regression analyses were carried out respectively based on sex, race, and BMI.

Results

After adjusting for confounding variables, snoring frequency was correlated with insulin concentration especially when snoring was at relatively high frequencies (e.g., more than 5 nights per week) (β = 1.77, 95%CI = 0.42–3.13, P = 0.010). The stratification analyses showed that high snoring frequency increased insulin secretion among women (β = 1.83, 95%CI = 0.05–3.62, P = 0.044), Hispanics (β = 3.28, 95%CI = 0.05–6.51, P = 0.047), and participants with BMI in the range > 30 kg/m² (β = 3.77, 95%CI = 0.52–7.03, P = 0.023).

Conclusion

Our results suggest that snoring is likely to relate to an increase in insulin when severe, especially in women, Hispanics, and people with a BMI of more than 30 kg/m².

中文翻译：

美国人群中打鼾与胰岛素水平之间的关联：一项横断面研究

目的

打鼾可能导致疲劳、肥胖等一系列问题，甚至引发严重疾病，但打鼾与胰岛素分泌之间具有重要临床意义的相关性却鲜有研究。本研究的目的是评估打鼾频率与胰岛素分泌之间的相关性，并讨论其潜在机制，从而评估打鼾个体的 β 细胞健康状况。

方法

该分析使用了 2015 年至 2018 年国家健康和营养检查调查 (NHANES) 的数据。对打鼾频率和胰岛素浓度进行回归分析，然后多元回归分析排除了与胰岛素分泌相关的各种因素，包括年龄、性别、种族、体重指数 (BMI)、指示患者营养状况的因素以及可能暗示阻塞性睡眠呼吸暂停的症状。随后，分别根据性别、种族和BMI进行三级多元回归分析。

结果

调整混杂变量后，打鼾频率与胰岛素浓度相关，尤其是当打鼾频率相对较高时（例如，每周超过 5 晚）（β = 1.77，95%CI = 0.42–3.13，P = 0.010）。分层分析表明，高打鼾频率增加了女性（β = 1.83，95%CI = 0.05–3.62，P = 0.044）、西班牙裔（β = 3.28，95%CI = 0.05–6.51，P = 0.047）、 BMI 范围 > 30 kg/m ²的参与者( β = 3.77, 95%CI = 0.52–7.03, P = 0.023)。