Interleukin-33 facilitates liver regeneration through serotonin-involved gut-liver axis,Hepatology

当前位置： X-MOL 学术 › Hepatology › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Interleukin-33 facilitates liver regeneration through serotonin-involved gut-liver axis
Hepatology ( IF 12.9 ) Pub Date : 2022-09-21 , DOI: 10.1002/hep.32744
Yankai Wen ₁ , Christoph Emontzpohl ₁ , Long Xu _{1,

2} , Constance L Atkins , Jong-Min Jeong ₁ , Yang Yang _{1,

2} , Kangho Kim ₁ , Chuan Wu ₃ , Shizuo Akira ₄ , Cynthia Ju ₁

Affiliation

Insufficient liver regeneration causes post-hepatectomy liver failure and small-for-size syndrome. Identifying therapeutic targets to enhance hepatic regenerative capacity remains urgent. Recently, increased IL-33 was observed in patients undergoing liver resection and in mice after partial hepatectomy (PHx). The present study aims to investigate the role of IL-33 in liver regeneration after PHx and to elucidate its underlying mechanisms.

中文翻译：

Interleukin-33 通过涉及血清素的肠肝轴促进肝脏再生

肝脏再生不足会导致肝切除术后肝功能衰竭和小体积综合征。确定增强肝脏再生能力的治疗靶点仍然紧迫。最近，在接受肝切除术的患者和部分肝切除术 (PHx) 后的小鼠中观察到 IL-33 增加。本研究旨在探讨 IL-33 在 PHx 后肝再生中的作用并阐明其潜在机制。

更新日期：2022-09-21

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11