The pandemic of COVID-19 was caused by a novel coronavirus termed as SARS-CoV2 and is still ongoing with high morbidity and mortality rates in the whole world. The pathogenesis of COVID-19 is highly linked with over-active immune and inflammatory responses, leading to activated cytokine storm, which contribute to ARDS with worsen outcome. Currently, there is no effective therapeutic drug for the treatment of COVID-19. Zinc is known to act as an immune modulator, which plays an important role in immune defense system. Recently, zinc has been widely considered as an anti-inflammatory and anti-oxidant agent. Accumulating numbers of studies have revealed that zinc plays an important role in antiviral immunity in several viral infections. Several early clinical trials clearly indicate that zinc treatment remarkably decreased the severity of the upper respiratory infection of rhinovirus in humans. Currently, zinc has been used for the therapeutic intervention of COVID-19 in many different clinical trials. Several clinical studies reveal that zinc treatment using a combination of HCQ and zinc pronouncedly reduced symptom score and the rates of hospital admission and mortality in COVID-19 patients. These data support that zinc might act as an anti-viral agent in the addition to its anti-inflammatory and anti-oxidant properties for the adjuvant therapeutic intervention of COVID-19.

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锌作为有效抗病毒剂的作用机制：COVID-19 的临床治疗意义

COVID-19 的大流行是由一种称为 SARS-CoV2 的新型冠状病毒引起的，并且在全世界范围内仍然以高发病率和死亡率持续发展。COVID-19 的发病机制与过度活跃的免疫和炎症反应高度相关，导致激活的细胞因子风暴，这导致 ARDS 的结果恶化。目前，尚无治疗 COVID-19 的有效治疗药物。已知锌可作为免疫调节剂，在免疫防御系统中发挥重要作用。最近，锌被广泛认为是一种抗炎和抗氧化剂。越来越多的研究表明，锌在几种病毒感染的抗病毒免疫中起重要作用。几项早期临床试验清楚地表明，锌治疗显着降低了人类鼻病毒上呼吸道感染的严重程度。目前，锌已在许多不同的临床试验中用于 COVID-19 的治疗干预。几项临床研究表明，使用 HCQ 和锌的组合进行锌治疗可显着降低 COVID-19 患者的症状评分以及住院率和死亡率。这些数据支持锌除了具有抗炎和抗氧化特性外，还可以作为抗病毒剂用于 COVID-19 的辅助治疗干预。几项临床研究表明，使用 HCQ 和锌的组合进行锌治疗可显着降低 COVID-19 患者的症状评分以及住院率和死亡率。这些数据支持锌除了具有抗炎和抗氧化特性外，还可以作为抗病毒剂用于 COVID-19 的辅助治疗干预。几项临床研究表明，使用 HCQ 和锌的组合进行锌治疗可显着降低 COVID-19 患者的症状评分以及住院率和死亡率。这些数据支持锌除了具有抗炎和抗氧化特性外，还可以作为抗病毒剂用于 COVID-19 的辅助治疗干预。