Hydrolysis of cellulose into C₆ sugars is the starting point and entry point for biomass refining and is an important pathway for biofuel production. However, biomass-based 2,5-furandicarboxylic acid (FDCA) is a highly catalytic promising but underutilized organic carboxylic acid. In this paper, we investigated the use of easily recoverable FDCA as a catalyst for the hydrolysis of cellulose to produce C₆ sugars in a γ-valerolactone/water (GVL/H₂O) green solvent system. FDCA has high inherent acidity (pKa = 2.76) and stability with unique solubility in aqueous solutions and many solvents. These properties allows it to meet both high temperature solubility for efficient homogeneous hydrolysis reactions and low temperature crystallization catalysts for high purity recovery. This process not only solves the problem of solid-solid mass transfer between solid acid and cellulose which limits the hydrolysis rate, but also eliminates the problem of difficult separation and recovery of liquid acid catalysts. The results showed when initial concentration of microcrystalline cellulose was 0.7 wt%（equivalent to 7 g/L）, and the initial dosage of FDCA was 2.0 wt%, the maximum yield of C₆ sugars reached 72.9% (40.1% glucose and 32.8% fructose) in GVL/H₂O (60/40, V/V) with a reaction at 200 °C for 30 min. More importantly, FDCA can achieve 80% recovery and ＞99% spectroscopic purity recovery. This study reveals the potential of FDCA as a catalyst in the catalytic conversion of biomass, which provides a new pathway for the green and efficient conversion of biomass resources.

纤维素水解成C ₆糖是生物质精炼的起点和切入点，是生物燃料生产的重要途径。然而，基于生物质的 2,5-呋喃二甲酸 (FDCA) 是一种具有高度催化潜力但未被充分利用的有机羧酸。在本文中，我们研究了使用易于回收的 FDCA 作为催化剂在 γ-戊内酯/水 (GVL/H _{2 ) 中水解纤维素生产 C 6糖}O) 绿色溶剂系统。FDCA 具有高固有酸度 (pKa = 2.76) 和稳定性，在水溶液和许多溶剂中具有独特的溶解性。这些特性使其能够满足高效均相水解反应的高温溶解度和高纯度回收的低温结晶催化剂。该工艺不仅解决了固体酸与纤维素之间固-固传质限制水解速率的问题，而且解决了液体酸催化剂难以分离回收的问题。结果表明，当微晶纤维素初始浓度为0.7 wt%（相当于7 g/L），FDCA初始用量为2.0 wt%时，C ₆糖的最大收率达到72.9%（葡萄糖40.1%和32.8%） GVL/H _{2中的果糖）}O (60/40, V/V) 在 200 °C 下反应 30 分钟。更重要的是，FDCA可以实现80%的回收率和＞99%的光谱纯度回收率。该研究揭示了FDCA作为催化剂在生物质催化转化中的潜力，为生物质资源的绿色高效转化提供了新途径。