Preservatives are frequently added to cosmetics to maintain product quality. Our laboratory quantifies 11 preservatives in cosmetics each year for regulatory purposes. In laboratories, many manufactures also analyze the preservatives in their products for quality control. To analyze many cosmetic samples, a rapid analysis method is required for efficiency. In this study, we developed a rapid method for the simultaneous determination of 11 regulated preservatives in cosmetics using a core-shell column by high-performance liquid chromatography. In this method, the 11 preservatives were separated within 17 min, which was approximately half the time reported in the previous study. The peak resolution for each preservative was >2.6, the correlation coefficients of the calibration curves were >0.9988, the percent recoveries were 92.0-111.9% and the relative standard deviations were <3.5% (n = 3). The relative standard deviations among 6 researchers were <4.7%. Thus, it is an effective rapid determination method for the analysis of preservatives in cosmetics.

中文翻译：

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使用核壳色谱柱快速测定化妆品中的防腐剂。

化妆品中经常添加防腐剂以保持产品质量。出于监管目的，我们的实验室每年都会对化妆品中的 11 种防腐剂进行定量。在实验室中，许多制造商还分析其产品中的防腐剂以进行质量控制。为了分析许多化妆品样品，需要一种快速分析方法来提高效率。在本研究中，我们开发了一种使用核壳柱通过高效液相色谱同时测定化妆品中 11 种受管制防腐剂的快速方法。在该方法中，11 种防腐剂在 17 分钟内分离，大约是之前研究报告时间的一半。每种防腐剂的峰分辨率 >2.6，校准曲线的相关系数 >0.9988，回收率百分比为 92.0-111.9%，相对标准偏差 <3.5% (n = 3)。6名研究人员的相对标准偏差<4.7%。因此，它是分析化妆品中防腐剂的有效快速测定方法。