Concentrated bone marrow aspirate (cBMA) has garnered widespread and increasing attention in recent years. We aimed to characterize the most influential articles in cBMA research while clarifying controversies surrounding its use and clinical efficacy and identifying important areas on which to focus future research efforts. The Science Citation Index Expanded subsection of the Web of Science Core Collection was systematically searched to identify the top 50 most cited publications on orthopaedic cBMA research. Publication and study characteristics were extracted, and Spearman's correlations were calculated to assess the relationship between citation data and level of evidence. The top 50 articles were published between the years 1996 and 2018, with 58% published in the year 2010 or later. Of the 29 studies for which level of evidence was assessed, the majority were Level IV (24, 83%). Twenty-one articles (42%) were classified as basic science or translational (9 cell culture, 8 animal study, and 4 using human blood samples). Application to treat cartilage defects was the most common focus of studies (17 studies, 34%), followed by analysis of cBMA composition (14 studies, 28%). No correlation was found between rank, citation rate, or year of publication and level of evidence. The most influential articles on cBMA are recent and consist of a majority low level of evidence studies. Cohort studies were the most common study type among the top 50 most cited articles, while basic science articles were relatively less common. These results suggest a rapidly evolving field with the potential to better explain inconsistent clinical results with improved understanding and documentation of basic science concepts in addition to large-scale, prospective clinical trials. Orthobiologics especially cBMA holds great promise for the future, and higher level clinical trials will help better define the best clinical uses for this treatment.

近年来，浓缩骨髓抽吸物（cBMA）引起了广泛且越来越多的关注。我们的目的是描述 cBMA 研究中最具影响力的文章，同时澄清围绕其使用和临床疗效的争议，并确定未来研究工作重点关注的重要领域。对 Web of Science 核心合集的 Science Citation Index Expanded 小节进行了系统搜索，以确定骨科 cBMA 研究中被引用最多的 50 篇出版物。提取出版物和研究特征，并计算斯皮尔曼相关性以评估引文数据和证据水平之间的关系。排名前 50 的文章发表于 1996 年至 2018 年之间，其中 58% 发表于 2010 年及以后。在评估证据级别的 29 项研究中，大多数为 IV 级（24 项，83%）。21 篇文章 (42%) 被归类为基础科学或转化文章（9 篇细胞培养、8 篇动物研究和 4 篇使用人类血液样本）。应用治疗软骨缺损是最常见的研究焦点（17 项研究，34%），其次是 cBMA 成分分析（14 项研究，28%）。排名、引用率或出版年份与证据水平之间没有发现相关性。cBMA 上最有影响力的文章是最近发表的，其中大部分是低水平的证据研究。队列研究是被引用次数最多的 50 篇文章中最常见的研究类型，而基础科学文章相对较少见。这些结果表明，这是一个快速发展的领域，除了大规模的前瞻性临床试验之外，还可以通过提高对基础科学概念的理解和记录来更好地解释不一致的临床结果。骨科生物制剂，尤其是 cBMA，未来前景广阔，更高水平的临床试验将有助于更好地确定这种治疗的最佳临床用途。