Sialic Acid 4-N-Piperazine and Piperidine Derivatives Bind with High Affinity to the P. mirabilis Sialic Acid Sodium Solute Symporter,ChemMedChem

当前位置： X-MOL 学术 › ChemMedChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Sialic Acid 4-N-Piperazine and Piperidine Derivatives Bind with High Affinity to the P. mirabilis Sialic Acid Sodium Solute Symporter
ChemMedChem ( IF 3.6 ) Pub Date : 2022-09-19 , DOI: 10.1002/cmdc.202200351
Tiago Bozzola ₁ , Richard E Johnsson ₂ , Ulf J Nilsson ₁ , Ulf Ellervik ₁

Affiliation

A new target: Bacterial sialic acid uptake inhibition is a promising strategy for the development of antibacterial drugs. In this study, we present the design, synthesis and evaluation of sialic acid 4-piperidine and piperazine derivatives a novel compound class, which bind the SiaT from Proteus mirabilis and target a different portion of the binding site.

中文翻译：

唾液酸 4-N-哌嗪和哌啶衍生物以高亲和力与奇异变形杆菌唾液酸钠溶质协同转运体结合

一个新靶点：抑制细菌唾液酸摄取是一种很有前途的抗菌药物开发策略。在这项研究中，我们介绍了唾液酸 4-哌啶和哌嗪衍生物的设计、合成和评估，这是一种新型化合物类，它结合奇异变形杆菌的 SiaT 并靶向结合位点的不同部分。

更新日期：2022-09-19

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11