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Understanding the anomaly of cis–trans isomerism in Pro-His sequence
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2022-09-19 , DOI: 10.1016/j.bmcl.2022.128985 Sunil K Gupta 1 , Shreya Banerjee 1 , Erode N Prabhakaran 1
中文翻译：
了解 Pro-His 序列中顺反异构的异常
更新日期：2022-09-23
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2022-09-19 , DOI: 10.1016/j.bmcl.2022.128985 Sunil K Gupta 1 , Shreya Banerjee 1 , Erode N Prabhakaran 1
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The anomalous absence of cisPro stabilizing CαHαXaa···πAro interactions at Xaa-Pro-Aro exclusively when Aro is His, is understood by NMR structural analyses of model peptides, as due to i → i backbone-side chain C6 H-bond that forms uniquely when Aro is His, which significantly decreases its χ1-g- population essential for CαHαXaa···πAro formation.
中文翻译：
了解 Pro-His 序列中顺反异构的异常
仅当 Aro 是 His 时，在 Xaa-Pro-Aro 上不存在 cisPro 稳定 C α H α Xaa ···π Aro相互作用的异常情况，这可以通过模型肽的 NMR 结构分析来理解，因为 i → i 主链侧链 C当 Aro 为 His 时唯一形成的6 H 键，显着降低了其 χ 1 -g - C α H α Xaa ···π Aro形成所必需的种群。
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