当前位置: X-MOL 学术Sleep Breath. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Association between brain-derived neurotrophic factor levels and obstructive sleep apnea: a systematic review and meta-analysis
Sleep and Breathing ( IF 2.1 ) Pub Date : 2022-09-17 , DOI: 10.1007/s11325-022-02707-x
Amirmohammad Khalaji 1, 2, 3 , Amir Hossein Behnoush 1, 2, 3 , Parnian Shobeiri 1, 2, 3, 4 , Behrad Saeedian 1, 2 , Antonio L Teixeira 5 , Nima Rezaei 2, 4, 6
Affiliation  

Purpose

Chronic intermittent hypoxia associated with obstructive sleep apnea (OSA) can affect neurons and glial cells, leading to cell stress and damage, and changes in brain-derived neurotrophic factor (BDNF) levels. This study investigated the relation between BDNF, OSA, and continuous positive airway pressure (CPAP) — the standard of care in patients with OSA.

Methods

Five databases were searched for studies that evaluated BDNF serum and/or plasma levels in patients with OSA and controls or publications assessing the effect of CPAP treatment on BDNF levels. We used standardized mean difference (SMD) with its 95% confidence interval (CI) comparison between patients with OSA and controls.

Results

Ten studies were included in our study assessing the relation between BDNF levels, OSA, and CPAP treatment. Five studies of BDNF levels in OSA compared to controls showed no significant difference (SMD = − 0.52, 95% CI [− 1.93; 0.89], p-value = 0.47). No statistically significant difference was found between CPAP treatment in patients with OSA and BDNF levels (SMD = − 0.78, 95% CI [− 1.77; 0.21], p-value = 0.12).

Conclusion

BDNF peripheral levels are not significantly altered in OSA or by its related treatment, preventing its use as a biomarker.



中文翻译:

脑源性神经营养因子水平与阻塞性睡眠呼吸暂停之间的关联:系统评价和荟萃分析

目的

与阻塞性睡眠呼吸暂停 (OSA) 相关的慢性间歇性缺氧会影响神经元和神经胶质细胞,导致细胞应激和损伤,以及脑源性神经营养因子 (BDNF) 水平的变化。本研究调查了 BDNF、OSA 和持续气道正压通气 (CPAP) 之间的关系——CPAP 是 OSA 患者的护理标准。

方法

在五个数据库中搜索了评估 OSA 患者和对照者 BDNF 血清和/或血浆水平的研究或评估 CPAP 治疗对 BDNF 水平影响的出版物。我们使用标准化均值差 (SMD) 及其 95% 置信区间 (CI) 对 OSA 患者和对照组进行比较。

结果

我们的研究中包括十项评估 BDNF 水平、OSA 和 CPAP 治疗之间关系的研究。与对照组相比,OSA 中 BDNF 水平的五项研究显示无显着差异(SMD = − 0.52,95% CI [− 1.93;0.89],p值 = 0.47)。OSA 和 BDNF 水平患者的 CPAP 治疗之间未发现统计学显着差异(SMD = − 0.78,95% CI [− 1.77;0.21],p值 = 0.12)。

结论

BDNF 外周水平在 OSA 或其相关治疗中没有显着改变,阻止其用作生物标志物。

更新日期:2022-09-19
down
wechat
bug