Background: Traumatic brain injury (TBI) is a serious hazard to human health and is characterized by high rates of disability and mortality. It is necessary to explore new effective treatment methods to reduce the impact of TBI on individuals and society. As an emerging neuromodulation technique, ultrasound is used to treat some neurological diseases, but the neuroprotective mechanism of low-intensity focused ultrasound (LIFUS) in TBI remains unclear. We aimed to investigate the protective effects and potential mechanisms of LIFUS in TBI.

中文翻译：

---

低强度聚焦超声通过 OX-A/NF-κB/NLRP3 信号通路减轻早期创伤性脑损伤

背景：创伤性脑损伤 (TBI) 是对人类健康的严重危害，其特点是致残率和死亡率高。有必要探索新的有效治疗方法，以减少TBI对个人和社会的影响。超声作为一种新兴的神经调节技术被用于治疗一些神经系统疾病，但低强度聚焦超声（LIFUS）对TBI的神经保护机制尚不清楚。我们旨在研究 LIFUS 在 TBI 中的保护作用和潜在机制。