Association between metabolic syndrome and osteoporosis among adults aged 50 years and older: using the National Health Information Database in South Korea,Archives of Osteoporosis

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Association between metabolic syndrome and osteoporosis among adults aged 50 years and older: using the National Health Information Database in South Korea
Archives of Osteoporosis ( IF 3.1 ) Pub Date : 2022-09-16 , DOI: 10.1007/s11657-022-01161-2
Sang Youl Rhee _{1,

2} , Dong Keon Yon ₂ , Mi Jung Kwon ₃ , Ji Hee Kim ₄ , Joo-Hee Kim ₅ , Woo Jin Bang ₆ , Jung Woo Lee ₇ , Bong-Cheol Kwon ₈ , Hyo Geun Choi _{9,

10} , Chanyang Min ₂

Affiliation

Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Department of Neurosurgery, Hallym University College of Medicine, Anyang, Korea.
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Department of Urology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Department of Orthopaedic Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea.
Department of Orthopaedic Surgery, Hallym University College of Medicine, Anyang, Korea.
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea.
Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, 14068, Republic of Korea.

Summary

This study aimed to examine the association between a history of metabolic syndrome (MetS) and osteoporosis with specific characteristics. The results showed that MetS was inversely associated with osteoporosis. In contrast, MetS was positively associated with osteoporosis in both obese men and postmenopausal obese women.

Purpose

Although several previous studies have investigated the association between MetS and osteoporosis, their findings remain controversial. This study aimed to examine the association between a MetS history and osteoporosis using a subset of data from a large, long-term, national database.

Methods

This nested case–control study used the National Health Information Database (NHID) of the Korea National Health Insurance Service (NHIS) from 2009 to 2017. Osteoporosis (n = 459,771) and control (n = 459,771) participants were matched in a 1:1 ratio by age, gender, income, and region of residence. MetS was defined based on the modified National Cholesterol Education Program-Adult Treatment Panel III criteria. Crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for osteoporosis in patients with MetS and its components were analyzed using logistic regression. Subgroup analyses were performed according to the combination of gender, menopausal status, and obesity status.

Results

The adjusted OR (95% CI) for osteoporosis in patients with MetS was 0.95 (0.94–0.96). This finding was consistent with the subgroup analyses in normal weight men, premenopausal (pre-MP) women with all obesity statuses, and postmenopausal (post-MP) underweight and normal weight women. In contrast, the opposite was observed for obese men (OR = 1.05, 95% CI = 1.01–1.09) and post-MP obese women (OR = 1.05, 95% CI = 1.01–1.08).

Conclusion

This study results suggested that MetS was associated with a low occurrence of osteoporosis. In contrast, MetS was associated with a high occurrence of osteoporosis in both obese men and post-MP obese women.

中文翻译：

50 岁及以上成年人代谢综合征与骨质疏松症的关联：使用韩国国家健康信息数据库

概括

本研究旨在检查代谢综合征 (MetS) 病史与具有特定特征的骨质疏松症之间的关联。结果表明，MetS 与骨质疏松症呈负相关。相比之下，MetS 与肥胖男性和绝经后肥胖女性的骨质疏松症呈正相关。

目的

尽管之前的几项研究已经调查了代谢综合征和骨质疏松症之间的关联，但他们的发现仍然存在争议。本研究旨在使用来自大型长期国家数据库的数据子集来检查 MetS 病史与骨质疏松症之间的关联。

方法

这项嵌套病例对照研究使用了 2009 年至 2017 年韩国国民健康保险服务 (NHIS) 的国家健康信息数据库 (NHID)。骨质疏松症 (n = 459,771) 和对照 (n = 459,771) 参与者在1 中匹配： 1 按年龄、性别、收入和居住地区划分的比率。MetS 是根据修改后的国家胆固醇教育计划-成人治疗小组 III 标准定义的。使用逻辑回归分析 MetS 及其成分患者骨质疏松症的粗略和调整比值比 (OR) 以及 95% 置信区间 (CI)。根据性别、绝经状态和肥胖状态的组合进行亚组分析。

结果

MetS 患者骨质疏松症的校正 OR (95% CI) 为 0.95 (0.94–0.96)。这一发现与正常体重男性、所有肥胖状态的绝经前 (pre-MP) 女性以及绝经后 (post-MP) 体重不足和正常体重女性的亚组分析一致。相比之下，肥胖男性 (OR = 1.05, 95% CI = 1.01–1.09) 和 MP 后肥胖女性 (OR = 1.05, 95% CI = 1.01–1.08) 的情况正好相反。