A novel quinazoline-based colorimetric sensor (probe 1) that detected Fe³⁺ via naked-eye in a buffered MeOH: H₂O (8:2) solvent system within a neutral pH range was synthesized and its structure was confirmed by ¹H-NMR, ¹³C-NMR, FT-IR, and Mass spectroscopy. Its photophysical properties were also studied. The sensitivity and selectivity factor in the presence of 16 metal ions was examined by utilizing absorption titrations. Based on the selectivity test, probe 1 exhibited excellent selectivity and sensitivity toward Fe³⁺ ions among various other ions. The competitive effect indicated relatively low interference of other cations on the interaction of probe 1/Fe³⁺. To specify the sensing behavior of probe 1 to Fe ³⁺, the mole ratio method was carried out. After addition of around 500 µL of Fe³⁺, the absorption of probe1 reached saturation, and the reaction was completed. The effect of pH on the absorption and stability of probe 1 towards Fe³⁺ was examined. The pH range from 5.0 to 9.0 was appropriate for detection of Fe³⁺. To find the binding stoichiometric of the complex, Job's plot studies were carried out by varying the molar ratio of Fe³⁺. A 1:2 binding ratio was proposed. Under the optimal conditions, a good linear relationship (R² = 0.9886) was at the concentration of Fe³⁺ over the range of 50–110 µM, with a detection limit of 47.44 nM. Our quinazoline-based probe has shown good results for the quantitative determination of Fe³⁺ in samples of urine with high recovery.

合成了一种新型的基于喹唑啉的比色传感器（探针 1），该传感器在中性 pH 范围内的缓冲 MeOH:H ₂ O (8:2) 溶剂体系中通过肉眼检测 Fe ^3+并通过1 H确认其结构-NMR、¹³ C-NMR、FT-IR和质谱。还研究了它的光物理性质。采用吸收滴定法检测了存在 16 种金属离子时的灵敏度和选择性因子。基于选择性测试，探针1对各种其他离子中的Fe ^{3+离子表现出优异的选择性和灵敏度。}竞争效应表明其他阳离子对探针 1/Fe ^{3+相互作用的干扰相对较低}. 为了指定探针1对Fe ³⁺的传感行为，进行了摩尔比法。加入约500 µL Fe ³⁺后，probe1的吸收达到饱和，反应完成。考察了pH对探针1对Fe ³⁺的吸收和稳定性的影响。5.0 至 9.0 的 pH 值范围适用于检测 Fe ³⁺。^{为了找到复合物的结合化学计量，通过改变 Fe 3+}的摩尔比进行乔布图研究。提出了 1:2 的结合比例。在最佳条件下， Fe ^{3+浓度呈良好的线性关系（} R ²  = 0.9886）在 50–110 µM 范围内，检测限为 47.44 nM。^{我们的喹唑啉基探针在尿液样品中 Fe 3+}的定量测定中显示出良好的结果，回收率高。